6-Methyl-3-pyrrolidino

Pentansaure 2-Diazo-4-methyl-3-pyrrolidino- -ethylester E14b, 1219f./E19d, 648 (Diazo-Verb. -f-En-amin)... 

H-Thiin (S)-4-[2-(Methoxy-methyl)-pyrrolidino]-5,6-dihydro- E21c, 2910 (Oxo -> En-NR2)... 

H-Thiin 6-Chloro-3,4-dimethyl-6-[2-(methoxy-methyl)-pyrrolidino-sulfonyl]-5,6-dihydro- -1-oxid E21e, 5060 (1,3-Dien +... 

The action of methylmagnesium iodide on 3-pyrrolidino-A -4-ketones (19) gives the 4a-methyl-4l -hydroxy steroids (20). ... 

Similarly alkylation (55) of l-N-pyrrolidino-2-methyl-l-propene (22) with propargyl bromide gave initial N alkylation to (23) with subsequent rearrangement to the allene (24). 

A particularly interesting case is the reaction of the enamino ketone (47), which under similar conditions gives the intermediate product (80), which then undergoes cyclization to the benzene derivative dimethyl 3-pyrrolidino-5-methyl phthalate (81). 

Enamines have been observed to act both as dienophiles (46-48) and dienes (47,49) (dienamines in this case) in one-step, Diels-Alder type of 1,4 cycloadditions with acrylate esters and their vinylogs. This is illustrated by the reaction between l-(N-pyrrolidino)cyclohexene (34) and methyl t/-a i-2,4-pentadienoate (35), where the enamine acts as the dienophile to give the adduct 36 (47). In a competitive type of reaction, however, the... 

Treatment of the pyrrolidine derivative 130 with sodium hydride followed by A-methyl piperazine afforded pyrrolidino[l,2-a]quinolinone 4-carboxy-late 131 (93JPR397) (Scheme 25). 

Carboxyl group of (-)-9-fluoro-3-methyl-7-oxo-10-[(3S)-3-(tert-butoxy-carbonylamino)pyrrolidino]-2,3-dihydro-7//-pyrido[l,2,3- 7e]-l,4-benzoxa-zine-6-carboxylic acid was converted into l-nitro-2-oxoethyl group in 45% yield by treatment with l,l -carbonyldiimidazole in boiling CFICI3 for 18h, then with MeN02 in the presence of KOr-Bu for another 18 h (96MI12). 6-(2,2-Diethoxycarbonyl)acetyl derivative formed from the aforementioned 6-carboxylic acid, when it was treated with l,l -carbonyldiimidazole in... 

The excess reducing agent is then decomposed by means of a little water (foaming), the solution is filtered and about 300 ml of water are added while stirring. The 3-N-pyrrolidino-4-phenoxy-5-sulfamylbenzoic acid methyl ester which has crystallized out is recrystallized from methanol in the form of colorless crystals, melting point 191°C to 192°C. 

Pyrrolidino-1 -(2-cyan-athyl)- 560 2-Pyrrolidino-l-methyl- 560 Tosylhydrazono- 371 4 -T osylhydrazono -1 - tert. -b u tyl - 36 9 (Tosyl-phenyl-hydrazono)- 368... 

A thiepin derivative (382) has been reported to be formed in the reaction of 3-methyl-4-pyrrolidinylthiophene with DMAD. The initial adduct, 5-pyrrolidino-2-thiabicyclo[3.2.0]hepta-3,6-diene (381), formed around —30°, isomerizes to dimethyl 6-methyl-5-pyrrolidinylthiepine-3,4-dicarboxylate (382) [Eq. (58)]. ... 

Anilino-ethyl)-5-phenyl-... 2- (3-Anilino-propyl)-5-phenyl-... 5- ( Imino-pyrrolidino-methyl)-amino -3-phenyl-... 

C6H5 —C-(CH2I2-N ) C6Hs no2 CHj - 5-(l,l-Diphenyl-3-pyrrolidino-prop-yl)-2-methyl-... 77 87-88,5 538... 

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