Piper amides biological activity

ABSTRACT An extensive compilation of structures of unsaturated amide products from Piper species (Piperaceae) with relevant literature references, and including a few representative examples of related compounds from other families, is presented. The biological activity attributed to Piper species, and many of the unsaturated amides they produce, includes organoleptic, medicinal and insecticidal effects and some of the more interesting biological properties are discussed in this chapter. Numerous synthetic approaches to the unsaturated amides have been developed, and a representative sampling of these strategies is presented. 

This chapter aims to provide a relatively comprehensive, yet inevitably not exhaustive, compilation of structures of amides isolated from Piper species (Tables 1 and 2). The chemistry and biological activity of some of these compounds as well as new developments in their synthesis are reviewed.2... 

J. C. do Nascimento, V. F. De Paula, J. M. David and J. P. David, Occurrence, Biological Activities and NMR Data of Amides from Piper (Piperaceae), Quim. Nova, 2012, 35, 2288. 

Decades of investigations in the natural products chemistry of the Piper genus yielded an important amount of monomeric and dimeric alkamides of diverse molecular architectures crnitributing to their biological activities [20-23,203,208-219]. Specifically, [4+2] dimers were isolated in P. chaba while [2 + 2] dimers were isolated in P. nigrum and P. longum, in both cases together with monomeric amides. 

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