Piezoelectric nucleic acid-based

New Frontiers in Nucleic Acid-Based Piezoelectric Biosensors ... 

Abstract Recent advances in nucleic acid-based detection coupled to piezoelectric transduction will be reported here. The main aspects involved in the development of nucleic acid sensors are considered the immobilization of the probe, the sample pretreatments (DNA extraction, amplification, denaturation of the amplified material), the sensitivity and specificity, etc. 

A biosensor is a device that combines a biological component a recognition layer) and a physico-chemical detector component (a transducer). The transduction unit can be electrochemical, optical, piezoelectric, magnetic, or calorimetric (1). Two groups of recognition molecules form the majority of biosensors affinity-based and catalytic-based biosensors. Affinity-based biosensors are used to bind molecular species of interest, irreversibly and noncatalytically. Examples include antibodies, nucleic acids, and... 

In this chapter, the main aspects related to piezoelectric sensing based on nucleic acids are considered and examples taken from different fields of appUcation, from environmental analysis to cUnical diagnostics, will be considered. 

The advent of new receptors based on nucleic acids, called aptamers, is a new challenge in piezoelectric sensing, not based on the hybridization reaction. The development of aptasensors has analogies to the introduction of immunosensing almost two decades ago the direct detection of analytes in complex matrices by immobilizing an optimized receptor on the sensing surface. 

Piezoelectric Based on nucleic acids To point mutation detection in... 

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