Physiological and pharmacological actions

Most often only one form shows correct physiological and pharmacological action. For example, only one enantiomer of morphine is active as an analgesic, only one enantiomer of glucose is metabolized in our body to give energy and only one enantiomeric form of adrenaline is a neurotransmitter. 

Determinations of the DA receptor subtypes responsible for physiological and pharmacological actions... 

There are a number of reasons to try to characterize dopamine receptor in addition to the fact that it is fashionable. Two of the major reasons well described by Goldberg and Kohli are (1) the importance of dopamine receptors subtypes responsible for physiological and pharmacological actions and (2) the utilization of the concept of selective dopamine receptors in the design and characterization of new drugs for cardiovascular and renal therapies. 

Based on the classic concept of "Diet and Medicine from the Same Source" described in old Chinese medical books, we have been using biochemical and pharmacological approaches to study natural products isolated from various medicinal plants and foodstuffs for about 20 years. In the present review, we examine the effects of natural products isolated from various medicinal plants and foodstuffs on the following physiological and pharmacological actions ... 

GABA - Of all the amino acid neurotransmitter candidates, GABA O) has been the most comprehensively studied. Numerous reviews have been published concerning the biochemical, physiological and pharmacological actions of GABA, one of the most recent of which appeared in Volume 13 of this series. Thus GABA will be discussed only in terms of the... 

Shanes AM (1958a) Electrochemical aspects of physiological and pharmacological action in excitable ceils. I. The resting cell and its alteration by extrinsic factors. Pharmacol Rev 10 59-164... 

The identification and characterization of prostanoid receptors has occurred during the past 10 years [11]. These results coupled with studies of PGHS and prostanoid receptor knockout mice have been critical to rationalize earlier results of studies on the physiological and pharmacological actions of prostanoids that had been somewhat confusing and difficult to interpret because PGs were found to cause such a wide variety of seemingly paradoxical effects. 

F.A. Dodge, Ionic Permeability Changes Underlying Nerve Excitation. Biophyacs of Physiological and Pharmacological Actions (AAAS, Washington, D.C., 1%1). 

Between 1910 and 1927 Dale published extensively on the physiological and pharmacological actions of histamine. Again, late in life he wrote ... 

When, shortly before the First World War, Henry Dale was making his exhaustive study of the physiological and pharmacological actions of histamine, a compound he and George Barger had discovered, he missed finding that histamine is a powerful stimulant of acid secretion, because he did not look for that property. His-... 

Alanine has potential usefulness as a transport inhibitor. However, it has physiological and pharmacological actions of its own, and there is a nonsaturable component to its uptake by the heart. Guanidinoethyl sulfonate, on the other hand, does not occur... 

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