Photochemical carcinogenesis

Manevich Y, Held KD, Biaglow JE (1997) Coumarin-3-carboxylic acid as a detector for hydroxyl radicals generated chemically and by gamma radiation. Radiat Res 148 580-591 Maples KR, Johnson NF (1992) Fiber-induced hydroxyl radical formation correlation with mesothelioma induction on rats and humans. Carcinogenesis 13 2035-2039 MarkG, Korth H-G, Schuchmann H-P, von Sonntag C (1996) The photochemistry of aqueous nitrate revisited. J Photochem Photobiol A Chem 101 89-103 Maskos Z, Rush JD, Koppenol WH (1990) The hydroxylation of the salicylate anion by a Fenton reaction and v-radiolysis a consideration of the respective mechanisms. Free Rad Biol Med 8 153-162... 

Interest in DNA-mediated CT has been spurred by its relevance to oxidative damage which might cause mutagenesis and carcinogenesis [2]. Thus, most research groups have focused their work on the photochemically or photophysically induced oxidation of DNA, and furthermore, on the mobility of the created positively charged radical in the DNA which, in fact, is a hole transfer (HT). Most experiments have been performed according to the steps [1] ... 

Oregno, I.F., Black, H.S., Kettler, A.H., and Wolf, J.E., Influence of dietary menhaden oil upon carcinogenesis and various cutaneous responses to ultraviolet radiation, Photochem. Photobiol., 49, 71, 1989. 

Fischer, M.A. and Black, H.S., Modification of membrane composition, eicosanoid metabolism, and immunoresponsiveness by dietary omega-3 and omega-6 fatty acid sources, modulators of ultraviolet-carcinogenesis, Photochem. Photobiol., 54, 381, 1991. 

UV-induced skin carcinogenesis by azthioprine (216), photochemical interaction between triamterene and hydrochlorthiazide (217) photochemistry of diclofenac (218), kinetic treatment of photochemical reactions (219) and a direct electron paramagnetic resonance (EPR) and spin-trapping study of light-induced free radicals from 6-mercaptopurine and its oxidation products (220). 

Kelly GE, Meikle WD, Moore DE. Promotion of UV-induced skin carcinogenesis by azathioprine role of photochemical sensitization. Photochem Photobiol 1989 49 59-65. Moore DE, MaUesch JL. Photochemical interaction between triamterene and hydro-chlorthiazide. Int J Pharm 1991 76 187-190. 

Naim, R.S., D.C. Morizot, S. Kazianis, A.D. Woodhead and R.B. Setlow. Nonmammalian models for sunlight carcinogenesis genetic analysis of melanoma formation in Xiphophorus hybrid fish. Photochem. Photobiol. 64 440-448, 1996. 

Data from animals and humans indicate that at least some photoirritants enhance UV-associated skin carcinogenesis. 8-Methoxypsoralen (8-MOP), used in psoralen plus UVA treatment therapy,12 is considered to be a photococarcinogen in humans, whereas several fluoroquinolones have been demonstrated to be photoirritants and photochemical carcinogens in hairless mice.11 However, data for many other classes of pharmaceuticals are unavailable. 

IV. TESTING FOR ENHANCEMENT OF UV-ASSOCIATED SKIN CARCINOGENESIS (DIRECT PHOTOCHEMICAL CARCINOGENICITY OR INDIRECT EFFECTS IN SKIN)... 

Black. H. S., and Chan, J. T. Experimental ultraviolet light-carcinogenesis. Photochem. Photobiol.,26 183-199,1977. 

Ananthaswamy, H.N. and PierceaU, W.E., Molecular mechanisms of ultraviolet radiation carcinogenesis, Photochem. PhotobioL, 52, 1119,1990. 

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