Phosphono lipid

Montier T, Cavalier A, Del6pine P, et al. (2003). The use of in situ hybridization to study the transgene pathway following cellular transfection with cationic phosphono-lipids. Blood Cells Molec. Dis. 30 112-123. 

The lipids of some organisms, such as Tetrahymena, contain aminoethylphosphonate, a compound with a C-P bond (Chapter 8). There are also many other naturally occurring phosphono compounds and huge quantities of synthetic phosphonates, present in detergents, herbicides, and insecticides, are metabolized by bacteria 297 Here we will consider only one step in the biosynthesis of phosphonates, the conversion of PEP into phosphonopyruvate (Eq. 13-54), a reaction catalyzed by PEP mutase. The phospho group is moved... 

Baer and Stanacev (1964) have reported the synthesis of dipalmitoyl L-a-glyceryl (2-aminoethyl) phosphonate, the first synthesis of a complex lipid containing phosphonic acid, and have shown spectra of L-a-(dipalmitoyl)cephalin and of dipalmitoyl L-a-phosphono(deoxy)cephalin. 

Deoxy-4-0-phosphono-3-0-tetradecanoyl-2-[(3R)- and 3S)-3-tetra-decanoyloxytetradecanamido]-D-glucose (16), a diastereomeric pair of derivatives related to bacterial lipid A, have been synthesized conventionally. Derivatives of lipid Y, a component of lipid A... 

The lipid analogues (98)-(100), in which the naturally occurring a-glycosyl prosphate group is replaced by a phosphono-oxyethyl group, have been made, the a-anomers having antitumour activity. ... 

The Lipid A analogues (84) - (88) have been synthesized. The 4,6-disulphated 1-thyminyl-analogue (85) had anti-HIV activity, while the analogues (86) and (87), in which the natural a-glycosyl phosphate moiety is substituted by a phosphono-oigrethyl group, had anti-tumour activity. ... 

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