Phosphatidylinositol-4-phosphate 5-kinase

P2 is generated from PtdIns(4)P by the enzymatic activity of phosphatidylinositol 4-phosphate 5-kinase (PDP5K) (Fig. 1). Additional pathways are likely to be discovered. 

NUCLEOSIDE DIPHOSPHATE KINASE 5-OXOPROLINASE PHENYLALANINE RACEMASE 1-PHOSPHATIDYLINOSITOL 4-KINASE PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE... 

Nishikawa, K., Toker, A., Wong, K., Marignani, P.A., Johannes, F.J., and Cantley, L.C., 1998, Association of protein kinase Cmu with type II phosphatidylinositol 4-kinase and type I phosphatidylinositol-4-phosphate 5-kinase. J. Biol. Chem. 273 23126-23133. 

Mikami, K., Katagiri, T., Iuchi, S., Yamaguchi-Shinozaki, K. and Shinozaki, K., 1998, A gene encoding phosphatidylinositol-4-phosphate 5-kinase is induced by water stress and abscisic acid in Arabidopsis thaliana. Plant J. 15 563-568. 

Rho with a 68-kDa phosphatidylinositol 4-phosphate 5-kinase in Swiss 3T3 cells. Mol. Biol. CeU. 1996 7 435-142. 160. 

Chong LD, Traynor-Kaplan A, Bokoch GM, Schwartz MA. The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells. Cel/79 507-513,1994. 

Rho proteins are involved in regulation of the actin cytoskeleton and induce formation of stress fibers and focal adhesions (Paterson et al., 1990 Ridley and Hall, 1992 Tominaga et al., 1993 Laudanna et al., 1996). Most probably independently of their role in actin regulation, Rho proteins have been proposed to participate as molecular switches in the control of phosphoinositide-3-kinase (Zhang et al., 1993), phosphatidylinositol-4-phosphate-5-kinase (Chong et al.. 

Chardin P, Boquet P, Madaule P et al. (1989) The mammalian G protein rhoC is ADP-ribosylated by Clostridium botulinum exoenzyme C3 and affects actin microfilaments in Vero cells. In EMBOJ. 8 1087-92 Chong LD,Traynor-Kaplan A, Bokoch GM eta/. (1994) The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells. In Cell 79 507-13... 

Moritz, A. Westerman, J. De Graan, P.N.E. Wirtz, K.W.A. Phosphatidylinositol 4-kinase and phosphatidylinositol-4-phosphate 5-kinase from bovine brain membranes. Methods EnzymoL, 209, 202-211 (1992)... 

PtdIns(4)P 5-kinase diphosphoinositide kinase phosphatidylinositol 4-phosphate kinase phosphatidylinositol-4-phosphate 5-kinase... 

Bazenet, C.E. Anderson, R.A. Phosphatidylinositol-4-phosphate 5-kinases from human erythrocytes. Methods Enzymol., 209, 189-202 (1992)... 

Galiano, F.J. Ulug, E.T. Davis, J.N. Overexpression of murine phosphatidylinositol 4-phosphate 5-kinase type Iff disrupts a phosphatidylinositol 4,5 hisphosphate regulated endosomal pathway. J. Cell. Biochem., 85, 131-145 (2002)... 

Loijens, J.C. Anderson, R.A. Type I phosphatidylinositol-4-phosphate 5-kinases are distinct members of this novel lipid kinase family. J. Biol. Chem., 271, 32937-32943 (1996)... 

Homma, K. Terui, S. Minemura, M. Qadota, H. Anraku, Y. Kanaho, Y. Ohya, Y. Phosphatidylinositol-4-phosphate 5-kinase localized on the plasma membrane is essential for yeast cell morphogenesis. J. Biol. Chem., 273, 15779-15786 (1998)... 

Vancurova, I. Choi, J.H. Lin, H. Kuret, J. Vancura, A. Regulation of phosphatidylinositol 4-phosphate 5-kinase from Schizosaccharomyces pombe by casein kinase I. J. Biol. Chem., 274, 1147-1155 (1999)... 

Barbieri, M.A. Heath, C.M. Peters, E.M. Wells, A. Davis, J.N. Stahl, P.D. Phosphatidylinositol-4-phosphate 5-kinase-lj5 is essential for epidermal growth factor receptor-mediated endocytosis. J. Biol. Chem., 276, 47212-47216 (2001)... 

Coppolino, M.G. Dierckman, R. Loijens, J. Collins, R.R Pouladi, M. Jong-stra-Bilen, J. Schreiber, A.D. Trimble, W.S. Anderson, R. Grinstein, S. Inhibition of phosphatidylinositol-4-phosphate 5-kinase la impairs localized actin remodeling and suppresses phagocytosis. J. Biol. Chem., 277, 43849-43857 (2002)... 

Tolias, K.F. Hartwig, J.H. Ishihara, H. Shibasaki, Y. Cantley, L.C. Carpenter, C.L. Type la phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly. Curr. Biol., 10, 153-156 (2000)... 

Other possible Rho effectors—atypical PKC and phosphatidylinositol-4-phosphate 5-kinase The protein kinase C family of ser/thr kinases is divided into three subfamilies, classical, novel, and atypical, with each class containing several isozymes. Classical PKCs are activated by Ca + and diacylglycerol and thus are typically activated downstream of phospholipase C activation. Novel PKCs are activated by diacylglycerol, and atypical PKCs are not activated by Ca or diacylglycerol and thus are not downstream of PLC [414]. Neutrophils contain classical isozymes a, Pj, and Pn, novel isozyme 8, and atypcial isozyme, [174, 200]. 

Honda, A., Nogami, M., Yokozeki, T., Yamazaki, M., Nakamura, H., Watanabe, H., Kawamoto, K., Nakayama, K., Morris, A. J., Frohman, M. A., and Kanaho, Y. (1999). Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation. Cell 99, 521-532. 

Jones, D. H., Morris, J. B., Morgen, C. P., Kondo, H., Irvine, R. F., and Cockcroft, S. (2000). Type I phosphatidylinositol 4-phosphate 5-kinase directly interacts with ADPribosylation factor 1 and is responsible for phosphatidylinositol 4,5-bisphosphate synthesis in the Golgi compartment. J. Biol. Chem. 275,13962-13966. 

Hernandez-Deviez, D. J., Roth, M. G., Casanova, J. E., and Wilson, J. M. (2004). ARNO and ARF6 regulate axonal elongation and branching through downstream activation of phosphatidylinositol 4-phosphate 5-kinase alpha. Mol. Biol. Cell IS, 111-120. 

---