Phosphatidylinositol-3-kinase polyphenols

Andreadi CK, Howells LM, Atherfold PA, Manson MM. 2006. Involvement of Nrf2, p38, B-Raf, and nuclear factor-kappaB, but not phosphatidylinositol 3-kinase, in induction of hemeoxygenase-1 by dietary polyphenols. Mol Pharmacol 69 1033-1040. 

The inhibitory effects of tea polyphenols on UVB-induced phosphatidylinositol-3-kinase (P13K) activation has been demonstrated in mouse epidermal JB6 Cl 41 cells. Pretreatment of cells with EGCG and TF-3 inhibited UVB-induced PI3K activation. Furthermore, UVB-induced activation of Akt and ribosomal p70S6 kinase (p °S6-K), PI3K downstream effectors, were also attenuated by these tea polyphenols. In addition to LY294002, a PI3K inhibitor, pretreatment with MAP-... 

Shih A, Zhang S, Cao HJ, Boswell S, Wu YH, Tang HY, Lennartz MR, Davis FB, Davis PJ, Lin HY (2004) Inhibitory effect of epidermal growth factor on resveratrol-induced optosis in prostate cancer cells is mediated by protein kinase C-alpha, Mol Cancer Ther 3 1355-1364 Siddiqui lA, Adhami VM, Afaq F, Ahmad N, Mukhtar H (2004) Modulation of phosphatidylinositol-3-kinase/protein kinase B- and mitogen-activated protein kinase-pathways by tea polyphenols in human prostate cancer cells. J Cell Biochem 91 232-242... 

Fig. 76.2 Polyphenols and polyphenol-rich sources induce endothelial-dependent NO- and EDH-mediated relaxations. Polyphenols are potent inducers of the oidothelial formation of nitric oxide (NO) and endothelium-derived hyperpolarizatitm (EDH) via a redox-soisitive mechanism. SKca small conductance calcium-activated potassium channels, IKca intermediate conductance calcium-activated potassium channels, Src Src family kinase, PI3K phosphatidylinositol 3-kinase, eNOS endothelial NO synthase, L-Arg L-arginine, sGC soluble guanylyl cyclase, GTP guanosine triphosphate, cGMP cyclic guanosine monophosphate, AA arachidonic acid, COX cyclooxygenase, ATP adenosine triphosphate, cAMP cyclic adenosine monophosphate...

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