Pheromonotropic activity associated with

It was reported earlier that PBAN is produced in the SOG (i). Because of significant pheromonotropic activity associated with the corpora cardiaca-corpora allata (CC-CA) complex, it was speculated that PBAN may be released... 

Figure 5. Pheromonotropic activity associated with (1) brain-suboesophageal ganglion, (2) corpora cardiaca-corpora allata (3) thoracic ganglia (4) three anterior abdominal ganglia (5) terminal abdominal ganglion and...

Pheromone production in females of many species of moths is controlled by a hormone, the pheromone biosynthesis activating neuropeptide (PBAN). PBAN was isolated from Helicoverpa Heliothls ) zea and identified as a 33 amino acid peptide. Amidation of the C-terminus is important for the biological activity of this hormone. Oxidation of two Met residues at postitions 5 and 14 enhanced pheromonotropic activity of PBAN. Stability of PBAN in saline can be increased by the substitution of Nle for Met at positions 5 and 14. Biological activity is mostly associated with brain-suboesophageal ganglion and corpora cardiaca of both female and male moths. Terminal abdominal ganglion does not appear to be directly involved in the control of pheromone production. PBAN is slowly degraded in hemolymph. Future possibilities of research on PBAN are discussed. 

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