Phenylethylamine molecule effects

Evaluation of Some Bicyclic Systems as Conformationally-Defined Phenylethylamines. X-Ray Crystallography. Perhaps the ultimate test of the suitability of a chemical structure for preparing conformationally-defined analogs would be their ability to produce biological effects identical to those of the parent compound. Since this ideal is rarely achieved, and since a "wrong" conformer should be inactive, it is useful to have other criteria with which to evaluate these systems. The bicyclic molecules to be examined in the present study are compounds I-VIII (Figure 7), benzobicyclo[2.2.2]octenes, benzobicyclo [2.2.1]heptenes, and 1,2,3,4-tetrahydro-l,4-epoxynaphthalenes. A number of structural parameters... 

A narrow substrate spectrum has been described for tiie yeast alcohol dehydrogenase (YADH) from Saccharomyces cerevisiae, making it a suitable biocatalyst only for molecules like methanol, ethanol, or in some cases acetone. Unfortunately the cofactor NADH is needed, which is regenerated by FDH (Scheme 29.6c). For the asymmetric synthesis of (S)-phenylethylamine with isopropylamine (IPA) as amino donor, acetone was converted to isopropyl alcohol catalyzed by YADH. The effectiveness of this method was compared to the reaction without YADH/FDH. A conversion yield of 99% was achieved with the YADH/FDH system while a conversion yield of 63-89% was obtained without YADH/FDH [69]. 

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