Phenyl piperidino

The isomers cis- and trans- bridged 1,5-oxazocines 410 were obtained by the oxidatively catalyzed condensation of tetrahydropyridine 541 with formaldehyde in 21% yield. From the reaction mixture were also isolated the phenyl-piperidino[4,5-<7]dioxanes 542 and 543 (6% and 15% yield, respectively) (Equation 24) <2004CHE641>. 

Tellurium Dichloro-(4-methoxy-phenyl)-piperidino- E12b, 346 (Cl - NR2)... 

SYNS KETONE, m-(BIS(2-CHLOROETHYL)AMINO)PHENYL PIPERIDINO PIPERIDINE, l-(m-(BIS(2-CHLOROETHYL)-AMINO)BENZOYL)-... 

Dithiolylium-4-olate, 5-phenyl-2-piperidino-IR, 6, 818 <76CB740, 78CB2021)... 

Displacement of Vinyl fluorine or chloride by secondary amines has given some unusual enamines as illustrated for the preparation of 1,1-difluoro-2-piperidino-3-phenyl-2-cyclobutene (151) (US), l,l-difluoro-2,4-dipiperidino-3-phenyl-2-cyclobutene (152) (114), and 2-phenyl-3-(l -aziridinyl)-2-cyclohexenone (153) (115). 

Azides can use enamines as dipolarophiles for ],3 cycloadditions to form triazolines. These azides can be formate ester azides (186), phenyl azides (187-195), arylsulfony] azides (191-193,196), or benzoylazides (197,198). For example, the reaction between phenyl azide (138) and the piperidine enamine of propionaldehyde (139) gives 1 -phenyl-4-methy l-5-( 1 -piperidino)-4,5-dihydro-l,2,3-triazole (140), exclusively, in a 53% yield (190). None of the isomeric l-phenyl-5-methyl product was formed. This indicates that the... 

The reaction mixture is boiled for half an hour under reflux. Thereafter the ether Is removed by distillation, until the inside temperature reaches 65°-70°C. The resulting benzene solution Is added to 95 cc concentrated hydrochloric acid containing ice for further processing. Thereby, 3-piperidino-1-phenyl-1-[A5-bicyclo-(2,2,1)-heptenyl-2]-propanol-1 of the summary formula is obtained. The compound melts at 101°C and its chloro-... 

A mixture of 23 parts of the ethyl ester of 4 phenylisonipecotic acid and 15 parts of 2,2-diphenyl-4-bromobutyronitrile in 19 parts of xylene is heated for 24 hours at 100°-120°C and then cooled and filtered to remove the precipitate of the hydrobromide of the ethyl ester of 4-phenylisonipecotic acid. The filtrate is then extracted with dilute hydrochloric acid and the extract is rendered alkaline by addition of concentrated aqueous potassium hydroxide and extracted with ether. This ether extract is treated with gaseous hydrogen chloride. The resulting precipitate is collected on a filter. The hydrochloride of the ethyl ester of 2,2 diphenyl-4-(4 -carboxy-4 -phenyl-1 -piperidino) butyronitrile thus obtained melts at about 220.5-222°C. See Meperidine hydrochloride for synthesis of 4-phenyl-isonipecotic acid ethyl ester. 

Chemical Name 3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylic acid 2-piperidino-ethyl ester hydrochloride... 

Photolysis of aryl azides in amine solution, with a tertiary amine as cosolvent to promote stabilization of the singlet nitrene, has met with some success. For example, the yield of 2-piperidino-3 W-azepme. obtained by the photolysis of phenyl azide in piperidine, is increased from 35 to 58% in the presence of A A /V. /V -tetramethylethylenediamine (TMLDA).180 Also, an improved yield (36 to 60 %) of A,(V-diethyl-3W-azepin-2-amine (38, R = Et) can be obtained by irradiating phenyl azide in triethylamine, rather than in dicthylaminc, solution.181 Photolysis (or thermolysis) of phenyl azide in TMEDA produces, in each case, 38 (R = Et) in 40% yield.181 In contrast, irradiation of phenyl azide in aniline with trimethylamine as cosolvent furnishes jV-phenyl-377-azepin-2-amine (32, R = Ph) in only low yield (2%).35... 

Phenyl-1,4-diaza-bicyclo[4.3.0]nonen-(4) mit Imidazolin-Struktur wird durch Natriumboranat zu 2-Piperidino-l-phenyl-athylamin aufgespalten4 ... 

Phenylsulfonyl-2-oxo-l-(4-methoxy-phenyl)- 633 3-Phenylsulfonyl-2-oxo-1 -phenyl- 633 2-Phenylthio-2-methyl- 500 2-Piperidino-l-(4-methyl-phenylthio)- 500... 

Piperidino-propyl)-(4-mcthyl-phenyl)- 500 Trichlormethyl-phenyl- 556... 

MethyI-(4-amino-phenyI)- 684 Methyl-benzyl- 500 Methyl-butyl- 500 Methyl-phenyl- 488, 500, 525 Methyl-propyl-. 500 PhenyI-(4-amino-phenyI)- 684 (2-Piperidino-propyl)-(4-methyl-phenyl)- 500... 

Quinoxalines with a cychc substituent other than an unsubstituted cycloalkyl, morpholino, phenyl, or piperidino group Quinoxalines bearing a substituent with more than six carbon atoms, except for an unsubstituted benzyl or benzoyl group Quinoxalines with two or more independent functional groups on a single substituent... 

The same heterobifunctional initiator, 2-phenyl-2-[(2,2,6,6-tetramethy-piperidino)oxy] ethyl 2-bromo-2-methyl propanoate, was employed for the synthesis of PMMA-fo-PfBuA-fo-PS triblock terpolymers via the combination of ATRP and NMP [136]. Styrene was initially polymerized through the alkoxyamine function in bulk at 125 °C, leading to PS chains with bromine end groups. Subsequent addition of fBuA in the presence of CuBr/PMDETA provided the PS-fr-PfBuA diblock. Further addition of CuCl, to achieve halogen exchange and MMA yielded the desired triblock copolymer with... 

However, when 6-bromo-4-phenylpyrimidine reacts with lithium piperi-dide/piperidine instead of potassium amide/liquid ammonia, it was surprisingly found that the corresponding 4-phenyl-6-piperidinopyrimidine was not obtained. Rather, the product was a compound whose structure was established to be a Z/E mixture of 2-aza-4-cyano-3-phenyl-l-piperidino-1,3-butadiene (2) (70RTC129). The presence of a cyano group in structure... 

Extension of these amination studies to 4-phenyl-, 4-methoxy-, and 4-piperidino-5-bromo[l(3)- N]pyrimidine revealed that also these com-... 

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