3- phenyl-3-pentanol

FIGURE 2.16 Concentration profiles of 5-phenyl-1-pentanol, obtained on Whatman No. 1 chromatography paper with w-octane as mobile phase. Concentrations of the analyte solutions in 2-propanol were (a) 0.25, (b) 0.50, (c) 0.75, and (d) 1.0 mol C [14,25]. 

FIGURE 2.19 Comparison of the concentration profiles of 5-phenyl-f-pentanol (dashed line) and benzophenone (thin solid line) developed as single analytes and as a binary mixture (bold solid line) concentration of 5-phenyl-1-pentanol in the sample was 1.50 mol 1" and that of benzophenone was 0.10 mol 1" . Microcrystalline cellulose was used as stationary phase and -octane as mobile phase [26]. 

The most spectacular peak profiles, which suggest self-associative interactions, were obtained for 5-phenyl-1-pentanol on the Whatman No. 1 and No. 3 chromatographic papers (see Figure 2.15 and Figure 2.16). Very similar band profiles can be obtained using the mass-transfer model (Eqnation 2.21), coupled with the Fowler-Guggenheim isotherm of adsorption (Equation 2.4), or with the multilayer isotherm (Equation 2.7). 

Schemes 5 and 6 outline the functionalization of a 10/1-Me by a steroidal 6/f-ol [1] and a 2/3-61 nitrite [6], Functionalization of 13/i-Me by a 20a-ol nitrite [7] and functionalization in the terpenoid field [8] are outlined in Schemes 7 and 8. The last example involves a 7-membered cyclic transition state that seldom occurs. Scheme 9 outlines a recent application of the Barton reaction in the synthesis of a biologically active carbacepham [9]. The photolysis of acyclic 5-phenyl-1-pentanol nitrite gives, preferentially, a nitroso dimer arising as a result of the abstraction of a hydrogen attached to the d-carbon, rather than the e-carbon from which the better stabilized benzyl radical can be generated (Scheme 10) [10].

More spectacular results are obtained with some alcohols. Figures 3 and 4 depict the densitometric profiles for 5-phenyl-1-pentanol chromatographed on Whatman No. 3 and Whatman No. 1 chromatography papers. 

Phenylpentan-1 -ol. See 5-Phenyl-1 -pentanol DL-1-Phenylpentan-2-ol. See a-Propylphenethyl alcohol... 

Phenylethyl acetate 2-Phenylethyl methyl ether 1-Phenyl-3-methyl-3-pentanol 5-Phenyl-1-pentanol o-Phenylphenol... 

Decahydro-3-naphthyl formate 10519-33-2 3-Decen-2-one 10521-91-2 5-Phenyl-1 -pentanol... 

Decahydro-6-naphthyl formate 234-059-0 3-Decen-2-one 234-064-8 5-Phenyl-1 -pentanol 234-065-3 Styryl acetate 234-072-1... 

The 1 -phenyl-pentanol-(1) may be prepared in any convenient manner. Benzaldehyde may be reacted with n-butyl-magnesium bromide, and after purification 1-phenyl-pentanol-(1) Is obtained in the form of a colorless oil at room temperature. 

In a second dendritic series, Frechet et al. [117] selected 4,4-bis (4 -hydroxy-phenyl)pentanol 42 as the branch cell reagent unit for construction of a more flexible dendron. This synthetic sequence is illustrated in Scheme 13-1, 2. 

S)-l-Phenyl-l-pentanol can be obtained, also in 98% ee, by addition of dibutylzinc to benzaldehyde in the presence of the disulfonamide/tetraisopropoxytitanium catalytic system26. 

S)-l-Phenyl-alhanol (-)-(S)-/- Phenyl-propanol ( +)-(S)-4-Methyl-pentanol-(2) ( +)—(S)-1- Cyclohexyl-athanol... 

In the two figures (Figure 2.15 and Figure 2.16), examples of the densitometri-cally recorded concentration profiles of 5-phenyl-l-pentanol, chromatographed on the two different types of chromatographic paper are shown. 

Now we are going to demonstrate mixed lateral interactions for the two different AB. .. B systems (the first composed of acid and ketone and the second composed of alcohol and ketone) and to discnss their impact on separation performance when using mild chromatographic cotrditiotrs (i.e., the low-active adsorbent and the low-polar eluent). As the binary test systems, we selected the 2-phenylbutyric acid-benzophenone mixture of analytes (i.e., acid and ketone) and the 5-phenyl-l-pentanol-benzophenone mixture of analytes (i.e., alcohol and ketone). Mixed associative dimers composed of the two pairs of analytes are schematically given in Figure 2.17. 

FIGURE 2.17 Schematic presentation of the mixed Lf-bonded associates of the acid and ketone (2-phenylbutyric acid-benzophenone) and of the alcohol and ketone (5-phenyl-l-pentanol -benzophenone). 

Die Photolyse von 4-Azido-3-phenyl-furazan-2-oxid in Dichlormethan/Ethanol fiihrt in einer stereoselektiven Reaktion zum (thermodynamisch weniger stabilen) (E)-2-Hydroximino-2-phenyl-acetonitril, bei der Pyrolyse (in Pentanol) entstehen sowohl das (E)- als auch das (Z)-Oxim426. 

II 5-Anilino-5-phenyl-pentan- 31 IV 5 Anilino-5-pkenyl-pentanol 86... 

N O-CeHs HNr 0 H2/Pd — C/C2H5OH, Normaldruck, 50 48h 1 HN- Y CsHs /-kAjHNy-OH 0 2-(2-A cetamino-3-phenyl-propyl-amino)-4-methyl-pentanol -too 2... 

L. Colombo et al.110) synthesized two related (S)-proline derivatives and used them as chiral ligands for lithium in reactions of n-butyllithium with benzaldehyde. 1-Phenyl-1-pentanol was obtained with moderate optical purity (4-33% e.e.). Both nitrogen atoms as well as the free hydroxy group in ligands (91) to (94) appear to be essential centers for coordination with the alkali metal. 

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