2-Phenyl-4,5-dihydro-l,3-thiazoles

Werden als Kondensationsmittel fur a-Thiocarbonylamino-carbonsaure-Derivate Carbonsau-reanhydride verwendet, kann es zu einer nachtraglichen O-Acylierung kommen. So handelt es sich bei einer Reihe von Produkten, die aus a-Thiobenzoylamino-carbonsauren und Acelan-hydrid erbalten wurden, nicht wie angegeben691 um 5-Oxo-2-phenyl-4,5-dihydro-l,3-thiazole, sondern um 5-Acetoxy-2-phenyl-l, 3-thiazole690. 

Methyl-2-phenyl-l, 3-thiazol ist unter formaler N,N-Dimethyl-acetamid-Abspaltung aus 5-Acetyl-4-dime-thylamino-5-methyl-2-phenyl-4,5-dihydro-l, 3-thiazol in Trifluor-essigsaure herstellbar932. 

Bei der Einwirkung von Tryptophan auf 5-(2-Carboxy-ethyl)-4-oxo-2-phenyl-4,5-dihydro-l, 3-thiazol unter hydrolytischen Oder oxidativen Bedingungen bildet sich liber intermediate 2-Oxo-gIutarsaure ein blaues Pigment1650. 

Hydroxy-5- (4-hydroxy-2 phenyl-4,5-dihydro-1,3-thiazol-4-yl)-2-phenyl-l, 3-thiazol4 5... 

Hydroxy-5-(4-hydroxy-2-phenyl-4,5-dihydro-1,3-thiazol-4-yl)-2-phenyl- 356 4-Hydroxy-2-[4-(l-hydroxy-2,2,2-trifluor-l-trifluormethyl-ethyl)-N-methyl-anilino]- 127 4-Hydroxy-5-(3-indolyl-methyl)-2-mercapto- 100 4-Hydroxy-2-isopropylamino-5-phenyl-... 

Mit Hilfe von Benzoesaure-chlorid-phenylimid ist es moglich, 2-Phenyl-4-oxo-4,5-dihydro-l,3-thiazol zu iminoacylieren1291 ... 

Trimcthyl- 408 4H-Pyrazol 409 i 3 4- (4-Brom-phenyl)-l-(4,5-diphenyl-l,3-thiazol- 2-yl)-2-oxo-2,3-dihydro- 68 5- Ethoxycarbonyl-4-mercapto-l-methyl- 339 5-Mercapto- 339 1-Methyl- 710 l-Methyl-2-(2-phenyl-4-trifluormethyl-1,3-thiazol-5-yl)- 293... 

Zur Bildung von 4-(4-Methyl-phenyl)-5-trifluormethyl-l,3-thiazol(70%) aus dem 5-Hydroxy-2,5-dihydro-Dcrivat mit Tctraphosphordecasulfid in Benzol s. Lit.1880. 

Methyl-2-(phcnylacetaminocarbonyl)-4-(2,2,2-Irichlor-ethoxycarbonyl)- 200 2-(2-Methyl-4-phcnyl-2,3-dihydro-l,3-thiazol-2-yl-mcthyl)-4-phenyl- 315... 

Diese Ausbeute wird nur bei sorgfaltiger Temperaturkontrolle erreicht. 3,5-Bis-f4-methyl-phenyl]-2H-l,4-thiazin wird mit Palladium/Kohle (10%) in Atha-nol, dann unter Zusatz von Platin(IV)-oxid in Athanol zum 2-Methyl-2,4-bis-[4-methyl-phenyf]-2,5-dihydro-1,3-thiazol (92% d.Th.) unter Ringverengung hydriert2 ... 

Hydrolysis of 3-alkyl-2-(isopropylidenehydrazono)-4-phenyl-2,3-dihydro-l,3-thiazoles 316 with concentrated hydrochloric acid proceeds via the intermediate 3-alkyl-2-hydrazono4-phenyl-2,3-dihydro-l,3-thiazoles 317 with ring expansion to the A -alkyl-5-phenyl-6/7-l,3,4-thiadiazine-2-amines 318 (Scheme 42) <1998HOU(E9c)483, 2006UP1>. 

Thiazole, 4,5-dihydro-2-[[l-(phenylmethyl)-2-propenyl] thio] - [52534-824], 78 Thiazole, 4,5-dihydro-2-[(phenylmethyl)-thio] - [41834-62-2], 82 Thiazole, 4,5-dihydro-2-[(3-phenyl-2-propenyl)thio] - [57620-95-8], 82 Thiazole, 4,5-dihydro-2-(2-propenylthio)-[3571-74-2],77... 

Thiazoline, 2-methylthio- [Thiazole, 4,5-dihydro-2-(methylthio)-j, 82 2-Thiazoline, 2-(4-phenyl-l -bu ten-3-yl)thio-[Thiazole, 4,5-dihydto-2-[ [Mphenyl-methyl)-2-propenylj thio] -], 78 Thiazolium,7V-methyl-2-methylthio-, iodide [Thiazolium, 4,5-dihydro-3-methyl-2-(methylthio)-, iodide], 80 Thioacetic acid, trifluoro-, S-ethyl ester [Ethanethioic acid, trifluoro-,5-ethyl ester], 125 Toluene [Benzene, methyl-], 85 Toluene, p-bromo- [Benzene, l-bromo-4-methyl-], 86... 

Rhodacyanines possess two chromophoric systems. They are at the same time neutrocyanine derivatives, which involves position 5 of the ketomethylene, and methine cyanine, which involves position 2. Following lUPAC s standard nomenclature rules, structure 7 is named 3-ethyl-4-phenyl-2- 4-oxo-3-ethyl-5-[2-(3-ethy]-2,3-dihydro-benzo-l,3-thiazo-lylidene)ethylidene]-tetrahydro-l,3-thiazolylidene-methyl -1.3-thiazolium iodide (Scheme 5). It implies that the 4-phenyl thiazole ring having the... 

Ausgehend von 2-(2-Phenyl-hydrazino)-l, 3-benzothiazol werden mit einem Aquivalent Tris-[dialkylami no]-phophan 3-Dialkylamino-2-phenyl-2,3-dihydro-benzo-thiazole) erhalten1044 ... 

Methyl-1,3-dihydropyrrolo[ 1,2-c]thiazole-6,7-biscarbamates have been described as active compounds against murine P388 lymphocytic leukemia <87JMC2109>. Several 5-aryl-2,3-dihydro-pyrrolo[2,l-fe]thiazole-6,7-dimethanol-6,7-bis(isopropylcarbamate)s were tested for growth inhibitory activity with the HL-60 human promyelocytic leukemia cell line. The 5-phenyl, 5-(4-fluorophenyl), and 5-(3,4-dichlorophenyl) have antileukemic activity. These compounds were also cytotoxic to HT-29 human colon carcinoma cells <88JMC1427>. 

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