Phenothiazines constipation with

Amantadine is used cautiously in patients with seizure disorders, psychiatric problems, renal impairment, and cardiac disease. Amantadine is a Pregnancy Category B drug and is used cautiously during pregnancy and lactation. Concurrent use of antihistamines, phenothiazines, tricyclic antidepressants, disopyramide, and quinidine may increase the anticholinergic effects (dry mouth, blurred vision, constipation) of amantadine... 

Additive effects are likely after concomitant use of nortriptyline with CNS depressants, including alcohol, analgesics, barbiturates, narcotics, tranquilizers, and anesthetics (oversedation) atropine and other anticholinergic drugs, including phenothiazines, antihistamines, meperidine, and antiparkinsonian agents (oversedation, paralytic ileus, visual changes, and severe constipation) and metrizamide (increased risk of convulsions). 

Sedative effects occur with most of the phenothiazines these drugs also act as antagonists at muscarinic and alpha adrenoceptors. Postural hypotension, blurring of vision, and constipation are common autonomic side effects, as is dry mouth. Effects on the male libido may result from increases in prolactin or from increased peripheral conversion of androgens to estrogens. The answer is (D). 

Clinically relevant interactions were not noted when moclobemide was given with one or more neuroleptics (including phenothiazines such as chlorpromazine, levomepromazine, thioridazine). Adverse effects such as hypotension, tachycardia, drowsiness, tremor, and constipation were somewhat more Sequent, probably due to additive effects. A fatal case of overdose with moclobemide and perazine was attributed to syn-ergisSc effects resulSng in funcSonal cardiovascular disorder. ... 

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