Phenones—

Benzhydrol (Diphenylcarbinol), (C HJ,CH OH, from Bettzo-phenone. The Meerwem-Ponndorf-Verley Reductions. 

Then add 3 drops of acetophenone (or about 0 3 g. of powdered benzo-phenone dissolved in 1 ml. of acetic acid) and shake the mixture. A precipitate of the phenylhydrazone is produced on scratching. 

Phenylpropanolamine. - With catalyst prepared as previously described from 0.5g of palladium chloride and 3g of charcoal, it was possible to reduce two portions of 9.8g of isonitrosopropio-phenone (0.06 mol), dissolved in 150 cc. of absolute alcohol containing 7. Og of hydrogen chloride, to phenylpropanolamine in from 145 - 190 minutes with yields of the isolated chloride from 9.4g to 11. Og, or 84 to 98% of the theoretical. After recrystallization from absolute alcohol the salt melted at 191°. The free base was obtained by treating an aqueous solution of the hydrochloride with alkali on cooling, the liberated amino alcohol solidified and after recrystallization from water melted at 103°."... 

Beiizoyl-3-methyl 1 Ethyl mcthylthiopropanoate, 2-aminobenzo-phenone, r-BuOCl 2 EtjN 3 Raney Ni 62, 89 [15]... 

Arylthiazoles were prepared either from w-formaminoaceto-phenones and phosphorus pentasulfide in 70% yield (47, 641) or by treating thioformaminoketones with concentrated sulfuric acid in water (344). Thioformaminoacetophenone itself was obtained by the action of potassium dithioformate on aminoacetophenone (251). 

The suffix phenone indicates that the acyl group is attached to a benzene ring)... 

Ultraviolet Photoinitiators. Photoinitiators are used in increasing volume for a multitude of appHcations. The most important of these are in the formulation of uv-curable inks and in the production of coatings on vinyl flooring, wood, and electronics components (28,29). The most common types of photoinitiators are phenone derivatives, for example, acetophenones and hen 7ophen ones (30). 

The photodecomposition of 2,1-benzisoxazolium salts gave iV-substituted phenones (Scheme 22). In one case the l-(adamantyl)-3-phenyl-2,l-benzisoxazolium cation (51) did not generate a substituted phenone with reductive ring substitution. Rather, adamantyl ring rupture occurred to produce (52) (Scheme 22) (78JOC123.3, 77JOC3929). 

Benzisoxazole N-oxides have recently been synthesized from 2-hydroxypropio-phenone oxime and lead tetraacetate (equation 63) (80CC421). 

Photolysis of phenacylamines (32) gives azetidin-3-ols (33) as minor products (66CC289). Higher and more consistent yields are obtained from photolyses of a-N-alkylamidoaceto-phenones (34), which gives N-tosylazetidines (35) in 74-95% yield (71JA2793). The key step... 

Trial runs demonstrated that one mole of benzalaceto-phenone required at least two moles of anhydrous aluminum chloride to complete the reaction at room temperature. When less aluminum chloride was used the yeUow addition product failed to dissolve entirely even after stirring for twenty-four hours, and the yield was decreased. 

Nuclear halogenation of acetophenone depends on formation of the aluminum chloride complex. If less than one equivalent of aluminum chloride is used, side-chain halogenation occurs. 3-Bromoacetophenone has been prepared from 3-aminoaceto-phenone by the Sandmeyer reaction. The synthesis described here has been taken from work of the submitters, who have used it to prepare many 3-bromo- and 3-chloroacetophenones and benzaldehydes, as well as more highly halogenated ones (Notes 7 and 8). 

Thus the unsaturated ketones carvone, eucarvone and 1-acetyl-cyclohexane formed the cyclopropyl ketones (6), (7) and (8) while benzalaceto-phenone (9) affords l-benzyl-2-pheny 1-cyclopropane as a mixture of as and irons isomers (10) and (H) 233,234... 

Solids. —It may Idc a hydrocM bon (c .g., paraffin wa, naphthalene) highei alcohol eg., cetyl alcohol) aldehyde e.g., z5-hydroxybenzaldehyde) ketone and qiiinonc e.g., benzo-phenone, camphor) acid (higher fatty, e.g., palmitic acid or aromatic acid) ester (of glycerol, phenols or aromatic alcohols) phenol e.g., thymol),... 

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