Phenols sulfoxides

Fenthion is very highly toxic to birds. The use of fenthion for control of mosquitos has been implicated in several bird kills, including recent incidents on Marco Island, Florida. The major metabolites, fenthion phenol sulfoxide and fenthion phenol sulfone, have very low toxicity to birds. 

Trilialophenols can be converted to poly(dihaloph.enylene oxide)s by a reaction that resembles radical-initiated displacement polymerization. In one procedure, either a copper or silver complex of the phenol is heated to produce a branched product (50). In another procedure, a catalytic quantity of an oxidizing agent and the dry sodium salt in dimethyl sulfoxide produces linear poly(2,6-dichloro-l,4-polyphenylene oxide) (51). The polymer can also be prepared by direct oxidation with a copper—amine catalyst, although branching in the ortho positions is indicated by chlorine analyses (52). 

Oxidative Reactions. The majority of pesticides, or pesticide products, are susceptible to some form of attack by oxidative enzymes. For more persistent pesticides, oxidation is frequently the primary mode of metaboHsm, although there are important exceptions, eg, DDT. For less persistent pesticides, oxidation may play a relatively minor role, or be the first reaction ia a metaboHc pathway. Oxidation generally results ia degradation of the parent molecule. However, attack by certain oxidative enzymes (phenol oxidases) can result ia the condensation or polymerization of the parent molecules this phenomenon is referred to as oxidative coupling (16). Examples of some important oxidative reactions are ether cleavage, alkyl-hydroxylation, aryl-hydroxylation, AJ-dealkylation, and sulfoxidation. 

Petroleum ether with aniline, benzyl alcohol, dimethyl formamide, dimethyl sulfoxide, formamide, furfuryl alcohol, phenol or water. 

Phenol Acidic Dimethyl sulfoxide Bifunctional (leans basic)... 

Dimethyl sulfoxide in the mobile phase acts as an intnnsic detector for certain phenols (e g dihydroxybenzenes) [194] on layers that have been treated with tin tungstate... 

Isotope labeling by derivative formation with deuterated reagents is useful for the preparation of analogs such as dg-acetonides, da-acetates, da-methyl ethers, dg-methyl esters, etc. The required reagents are either commercially available or can be easily prepared. (The preparation of da-methyl iodide is described in section IX-F. Various procedures are reported in the literature for the preparation of dg-acetone, da-diazometh-ane57.i63.i73 and da-acetyl chloride. ) These reactions can be carried out under the usual conditions and they need no further discussion. A convenient procedure has been reported for the da-methylation of sterically hindered or hydrogen bonded phenolic hydroxyl functions by using da-methyl iodide and sodium hydroxide in dimethyl sulfoxide solution. This procedure should be equally applicable to the preparation of estradiol da-methyl ether derivatives. 

The methyl group on a sulfoxide interestingly proves sufficiently acidic to substitute for phenolic hydroxyl. The preparation of this combined a- and 3-blocker, sulfinalol, begins by protection of the phenolic hydroxyl as its benzoate ester (34). Bromination (35) followed by... 

The electronic effects of many substituents have been examined by studies of PMR118,119 sulfinyl and sulfonyl groups have been included in some of these. For example, Socrates120 measured the hydroxyl chemical shifts for 55 substituted phenols in carbon tetrachloride and in dimethyl sulfoxide at infinite dilution, and endeavored to... 

Natriumboranat reduziert Nitroso-benzol in Athanol bei 30° zu Azoxybenzol (75% d.Th.), in Dimethyl-sulfoxid bei 85°zu Azobenzol (78% d.Th.)"1 und4-Nitroso-phenol, in Wasserbei 60°zu 4-Amino-phenol (42%... 

When thionyl chloride is used, diaryl sulfoxides are usually the main products. Unsymmetrical diaryl sulfides can be obtained by treatment of an aromatic compound with an aryl sulfenyl chloride (ArSCl) in the presence of a trace amount of iron powder.Aromatic amines and phenols can be alkylthiolated (giving mostly ortho product) by treatment with an alkyl disulfide and a Lewis acid catalyst. With certain substrates (primary amines with a chloro group, or a group not replaceable by chloro, in the para position), treatment with S2CI2 and NaOH gives thiophenolate salts ... 

Phenolic aromatic sulHdes, sulfoxides, sulfones [10] Diuretics [11]... 

Phenol, the simplest and industrially more important phenolic compound, is a multifunctional monomer when considered as a substrate for oxidative polymerizations, and hence conventional polymerization catalysts afford insoluble macromolecular products with non-controlled structure. Phenol was subjected to oxidative polymerization using HRP or soybean peroxidase (SBP) as catalyst in an aqueous-dioxane mixture, yielding a polymer consisting of phenylene and oxyphenylene units (Scheme 19). The polymer showed low solubility it was partly soluble in DMF and dimethyl sulfoxide (DMSO) and insoluble in other common organic solvents. 

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