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Phenols and Aryl Halides Nucleophilic Aromatic Substitution

PHENOLS AND ARYL HALIDES NUCLEOPHILIC AROMATIC SUBSTITUTION [Pg.530]

Electron-releasing —CH3 destabilizes the anion more than the acid, p ai larger than for phenol. [Pg.530]

Electron-withdrawing chlorine stabilizes the anion by dispersing the negative charge. pXais smaller than for phenol. [Pg.530]

Nitro groups are very powerM electron-withdrawing groups by their inductive and resonance effects. Resonance structures (B-D) below place a positive charge on the hydroxyl [Pg.530]

3 Dissolve the mixture in a solvent such as CH2CI2 (one that is immiscible with water). Using a separatory funnel, extract this solution with an aqueous solution of sodium bicarbonate. This extraction will remove the benzoic acid from the CH2CI2 solution and transfer it (as sodium benzoate) to the aqueous bicarbonate solution. Acidification of this aqueous extract will cause benzoic acid to precipitate it can then be separated by filtration and purified recrystallization. [Pg.531]


CHAPTER 21 PHENOLS AND ARYL HALIDES Nucleophilic Aromatic Substitution... [Pg.946]

PHENOLS AND ARYL HALIDES NUCLEOPHILIC AROMATIC SUBSTITUTION 531... [Pg.531]




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And nucleophilic aromatic substitution

And nucleophilic substitution

Aromatic halides

Aromatic nucleophiles

Aromatic substitution nucleophilic

Aryl halides aromatic

Aryl halides nucleophilic aromatic substitution

Aryl halides nucleophilic substitution

Aryl halides substitutions

Aryl nucleophiles

Aryl substituted

Aryl-substitution

Halide nucleophilicities

Halides aromatic nucleophilic substitution

Halides nucleophilicity

Nucleophile aromatic substitution

Nucleophile phenol

Nucleophilic aromatic

Nucleophilic aromatic substitution nucleophiles

Nucleophilic aryl substitution

Nucleophilic arylation

Phenols arylation

Phenols nucleophilic aromatic substitution

Substituted halides

Substituted phenols

Substitution halides

Substitution, aromatic, and

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