Phenolphthalein tablets

In pharmaceutical drug analysis a host of organic pharmaceutical substances are invariably converted quantitatively to their corresponding derivatives by virtue of interactions with certain functional entities, namely aldehyde, ketone, amino, carboxyl, phenolic, hydroxyl etc. However, in some cases it may be feasible to obtain uniform substitution products of organic pharmaceutical substances quantitatively, for instance tetraido derivative of phenolphthalein is obtained from the phenolphthalein tablets. It is important to mention here that the number of organic pharmaceutical substances which may be analysed by this method is limited because of two vital reasons, they are ... 

Phendimetrazin Tablets (35 mg) Phenindion Tablets (50 mg) Phenolphthalein Tablet Cores (200 mg) Phenytoin Oral Suspension (5%) Phenytoin Sodium Tablets (100 mg),... 

Experiments are described for determining GO2 in carbonated beverages, NaHG03 in Alka-Seltzer tablets, and the molecular weight of GO2. Garbon dioxide is collected in NaOH and the concentrations of G03 are determined by titrating with a standard solution of HGl to the phenolphthalein and methyl orange end points. 

Bisacodyl is available in tablet and suppository formulations for the treatment of acute and chronic constipation. It also is used in conjunction with PEG solutions for colonic cleansing prior to colonoscopy. It induces a bowel movement within 6-10 hours when given orally and 30-60 minutes when taken rectally. It has minimal systemic absorption and appears to be safe for acute and long-term use. Phenolphthalein, another agent in this class, was removed from the market owing to concerns about possible cardiac toxicity. 

Assessment of indomethacin powder had been specified in the U.J5. XIX and the British Pharmacopeia, 1980 as a back titration with hydrochloric acid after alkaline hydrolysis(13,14). This method can attain a precision of + 0.8%(62). A direct titration for tablets and capsules is described using sodium hydroxide. If performed rapidly with phenolphthalein indicator, a precision of +0.3% is attainable. 8 The latter procedure serves to differentiate ester formation as well as hydrolysis products from intact material. The presence of parachlorobenzoic acid and 5-methoxy-2-methylindole-3-acetic acid are cause for positive error. 

Phenolphthalein and aloin levels in tablet formulations were quantitated using a silica column (>l = 249nm) and an 88/12/0.5 chloroform/methanol/acetic acid mobile phase [797]. Good peak shapes resulted and elution was complete in 3 min A potential problem with this analysis is that the phenolphthalein eltued very near the void volume. Any baseline disturbance due to the injection could therefore create difficulties for reproducibly quantitating phenolphthalein. A plot of k versus percent chloroform (fiom 80% to 96%) gives the reader excellent information as to the choice of a mobile phase that would be more likely to generate a robust method. 

Tablets and pills, such as Compound Pills of Phenolphthalein, B.P.C. (containing grain) Compound Tablets of Phenolphthalein,...

Dissolve as completely as possible a quantity of powdered pills or tablets expected to contain about 10 mg of phenolphthalein in 100 ml of 95 per cent ethanol. Allow any insoluble matter to settle and apply the general method for colour development to 5 ml of the clear supernatant liquid. 

Tablets of Phenolphthalein, B.P. The tablets usually, contain 2 grains of phenolphthalein and are made with a chocolate base.

Triturate a weight of powdered tablets equivalent to about 0 25 g of phenolphthalein with ten times its weight of anhydrous sodium sulphate and extract with six quantities, each of 20 ml, of light petroleum (b.p. 40 to 60 ). Reject the petroleum extracts and extract the residue with six quantities, each of 20 ml, of ether. Combine the ether extracts, evaporate the ether and dry the residue of phenolphthalein to constant weight at 105... 

To determine the alkalinity, dissolve a known weight of tablets in 0 1 N hydrochloric acid, boil to eliminate carbon dioxide and titrate back to phenolphthalein. 

Urease test (specific for urea). Add a few drops of phenolphthalein to a solution of 0 - 2 g of the substance in 5 ml of water, followed by a pinch of jack bean meal or a crushed urease tablet. Shake the mixture, which slowly becomes pink due to the hydrolysis of urea to ammonium carbonate (alkaline). 

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