Phenobarbital chemical structure

In this study, potential oscillation was measured in the presence of lOOmM sodium salts of barbital, allobarbital, phenobarbital, and amobarbital in phase wl [19]. Their chemical structures are shown in Fig. 15. Amplitude and the oscillatory and induction periods were noted to depend on the particular hypnotic used. Amplitude decreased in the order, barbital > allobarbital > phenobarbital > amobarbital. The oscillatory period increased in the order, barbital < allobarbital < phenobarbital < amobarbital. Induction period increased in the order, barbital < allobarbital < phenobarbital < amobarbital. These parameters changed depending on drug concentration. Hypnotics at less than 5 mM had virtually no effect on the oscillation mode. 

FIG. 15 Chemical structures of (a) sodium barbital, (b) sodium allobarbital, (c) sodium phenobarbital, and (d) sodium amobarbital. 

By chemical structure—For example, the barbiturates (such as phenobarbital, Amytal, and Seconal) are synthetic compounds derived from the chemical structure... 

Primidone is chemically and structurally similar to phenobarbital with the exception that the carbonyl group on Cj is replaced by a methylene group. This modification leads to the production of a drug with strong anticonvulsant properties without expressed soporific effects. 

Figure 6 Space-filled molecular structures of cytochromes P450 I substrates and inducers (dibenzanthracene, 9-hydroxyellipticine, and 7-ethoxyresorufin) compared with chemicals that act as substrates for cytochromes P450 II (phenobarbital, metyrapone, and hexobarbital).

Dormitivity — construed as a second-order property — has first-order chemical-realizing properties such as (having the) structure C12H12N2O3 (phenobarbital) that causes sleep. What is the relation between a second-order property and the disjunction of its first-order realizers if not identity By the disjunction I mean the property that consists in being C12H12N2O3 (phenobarbital) or in being Q HijClNjO (diazepam), or...But what... 

The useful antiepileptic agents belong to several chemical classes. Most of the drugs introduced before 1965 are closely related in structure to phenobarbital, the oldest member of this therapeutic class. These include the hydantoins, phenytoin, mephenytoin, and ethotoin the deoxybarbiturate, primidone the oxazolidine-diones, trimethadione, and paramethadione and the succinimides, ethosuximide, methsuximide, and phensuximide. The agents introduced after 1965 include the benzodiazepines clonazepan and clorazepate, an iminostilbene, carbamazepine, and a branched-chain carboxylic acid, valproic acid. 

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