Phenergan - Promethazine hydrochloride

Each teaspoon (5 mL) of Phenergan Syrup Fortis contains 25 mg promethazine hydrochloride in a flavored syrup base with a pH between 5.0 and 5.5 alcohol, 1.5%. The inactive ingredients present are artificial and natural flavors, citric acid, saccharin sodium, sodium benzoate, sodium propionate, water, and other ingredients. 

Perennial and seasonal allergic rhinitis Promethazine hydrochloride Phenergan Ascorbyl palmitate, silicon dioxide, white wax, and cocoa butter... 

Promethazine Hydrochloride, USP. Proitictlianne hydnxihloridc, ( )IO- 2-(dimcthylamino)propyl phenolhi-azine monohydrochloride (Phenergan), occurs as a whileo faint-yellow crystalline powder that is very soluble In wain. 

Example Promethazine hydrochloride (Phenergan) Route PO/IM/ Pregnancy category C Rectal/TV Pharmacokinetic Well absorbed from GI tract, after IM administration Widely distributed metabolized in liver excreted in urine PB 60%-90%... 

Although topical phenothiazine antihistamine preparations such as promethazine hydrochloride (Phenergan) cream are no longer used in the United States, such topical antihistamine preparations are still widely used in Europe. Individuals who have become sensitized by such topical phenothiazine antihistamines often suffer a flare of the dermatitis when a phenothiazine antihistamine is taken, i.e., a systemic eczematous contact dermatitis. In addition, many individuals acquire allergic sensitization to various phenothiazine drugs which show cross-reactions with the phenothiazine antihistamines. Table 6 lists the phenothiazine antihistamine compounds. 

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