Pharmacology protein expression

Myers TG et al. A protein expression database for the molecular pharmacology of cancer. Electrophoresis 1997 18 647-653. 

Auricchio, A., Behling, K.C., Maguire, A.M., et al. (2002). Pharmacological regulation of protein expression from adeno-associated viral vectors in the eye. Mol. Ther., 6, 238-242. 

In many systems delta receptors appear to be promiscuous with regard to their ability to interact with a variety of G proteins of the Gi/o family. The actual combinations of Ga and Gpy with which the receptor interacts are likely to be governed by the types and amounts of G protein expressed in particular cells, and the physiological and pharmacological outcome by the ability of particular G proteins to modulate various downstream effectors. 

Bryant CE, Perretti M and Flower RJ, Suppression by dexamethasone of inducible nitric oxide synthase protein expression in vivo - A possible role for lipocortin 1. Biochemical Pharmacology 55(3)) 279-285, 1998. 

Cooper, S.R. Taylor, J.K. Miraglia, L.J. Dean, N.M. Pharmacology of antisense oligonucleotide inhibitors of protein expression. Pharmacol. Ther. 1999, 82, 427-435. 

Dallas, S., Miller, D. S., 8c Bendayan, R. (2006). Multidrug resistance-associated proteins Expression and function in the central nervous system. Pharmacological Reviews, 58, 140—161. 

Yan and his colleagues used a stable isotope labeled proteome internal standard to analyse protein expression alterations during oxidative stress in breast epithelial cells. Affinity chromatography was combined with MS/MS in the proteomic analysis of human 06-methylguanine-DNA methyltransferase. These studies demonstrated that proteomics can elucidate protein expre-ssions associated with the pharmacological and toxic effects of an anticancer drug when integrated with other biochemical methods. 

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