Pharmacology gastrointestinal system

The most prominent pharmacologic effects of cholinesterase inhibitors are on the cardiovascular and gastrointestinal systems, the eye, and the skeletal muscle neuromuscular junction (as described in the Case Study). Because the primary action is to amplify the actions of endogenous acetylcholine, the effects are similar (but not always identical) to the effects of the direct-acting cholinomimetic agonists. 

Kinter LB (2003) Safety pharmacology of the renal and gastrointestinal systems. In Williams PD, Bass AS (eds) Safety pharmacology A practical guide. Therlmmune Research, Gaithersburg, MD, pp 99-116... 

Determine safety pharmacology profile in central nervous, cardiovascular, respiratory, renal, and gastrointestinal systems. 

The five organ functions assessed in safety pharmacology are the cardiovascular system, nervous system, respiratory system, gastrointestinal system and renal system. To these we would add general systemic metabolic functions, as these are amenable to collectiOTi of at least some biochemical and physiological data. 

Clinical pharmacological studies to specifically address the effect of rifaximin on GI or CY and respiratory functions have not been performed. However, while the most frequently reported, albeit few, adverse events associated with rifaximin administration were gastrointestinal in nature, no untoward reactions involving the CV or respiratory systems have been described [33, 117]. 

---