Pharmacokinetics tolerance

Pharmacodynamic tolerance to barbiturates develops over weeks to months, whereas pharmacokinetic tolerance occurs in a period of days. At maximum tolerance, the dosage of a barbiturate may be six times the original dosage. 

Alderman, J., Wolkow, R., Chung, M., and Johnston, H.E (1998) Sertraline treatment of children and adolescents with obsessive-compulsive disorder or depression pharmacokinetics, tolerability, and efficacy. / Am Acad Child Adolesc Psychiatry 37 386-394. 

The West Discovers Tobacco Tobacco as Panacea From Panacea to Panned Prevalence of Tobacco Use Smoking in the United States Initiation of Smoking Smokeless Tobacco Use Pharmacology of Nicotine Sites of Action Pharmacokinetics Tolerance and Dependence Tolerance... 

Sites of Action Pharmacokinetics Tolerance and Dependence Caffeine Withdrawal Tolerance... 

Conclusions of no effect are based upon the pharmacokinetic tolerances accorded to generic versus innovative products. However, small numbers of patients usually make this quite difficult. 

I=t s 35 fd PHARMACOKINETICS TOLERANCE /DEPENDENCE DRUG INTERACTIONS NOTES... 

A Phase I clinical study, performed in the U.K. under the auspices of the Cancer Research Campaign, completed enrolment in August 2001 The primary objectives of this study were to determine pharmacokinetics, tolerance, and maximum tolerated dose of CT-2103 when administered every 21 days, and to propose a suitable dose for further evaluation in Phase II studies. A secondary objective was to observe for potential antitumour effects in taxane-naive patients. ... 

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