Pharmacokinetics and Drug Interactions

For more information on the side effects, pharmacokinetics, and drug interactions of specific agents, refer to Chap. 71 on Schizophrenia, Chap. 70 on Major Depressive Disorder, and Chap. 52 on Epilepsy. 

Wire MB, Shelton MJ, Studenberg S (2006) Fosamprenavir Clinical pharmacokinetics and drug interactions of the amprenavir prodrug. Clin Pharmacokinet 45 137-168. 

Ciismon, M.L. (1998) Pharmacokinetics and drug interactions of cholinesterase inhibitors administered in Alzheimer s disease. Pharmacotherapy, 18, 47-54. 

Venkatakrishnan, K and Obach, R.S. (2005) In vitro-in vivo extrapolation of CYP2D6 inactivation by paroxetine prediction of nonstationary pharmacokinetics and drug interaction magnitude. Drug Metabolism and Disposition ... 

Drug interactions In a randomized, double-blind study, Zenapax or placebo was added to an immunosuppressive regimen of cyclosporine, mycophenolate mofetil, and steroids to assess tolerability, pharmacokinetics, and drug interactions. The addition of Zenapax did not result in an increased incidence of adverse events or a change in the types of adverse events reported. The following medications have been administered in clinical trials with Zenapax with no incremental increase in adverse reactions cyclosporine, mycophenolate mofetil, ganciclovir, acyclovir, azathioprine, and corticosteroids. 

FIG. 3-1. Single-dose plasma drug concentration versus time curves for the same dose of the same drug given to the same individual by three different routes. (From Janicak PG, Davis JM. Pharmacokinetics and drug interactions. In Sadock BJ, Sadock V, eds. Kaplan Sadock s comprehensive textbook of psychiatry, Vol. 2, 7th ed. Philadelphia Lippincott Williams Wilkins, 2000 2251, with permission. Artwork created by Matthew Janicak.)... 

Janicak PG, Davis JM. Pharmacokinetics and drug interactions. In BJ Sadock, V Sadock, eds. Kaplan Sadock s comprehensive textbook of psychiatry, Vol. 2, 7th ed. Philadelphia Lippincott Williams Wilkins, 2000 2250-2259. 

Cohen LJ. Principles to optimize drug treatment in the depressed elderly practical pharmacokinetics and drug interactions. Geriatrics 1995 50(suppl 1) S32-S40. 

To discuss the pharmacokinetics and drug interactions of atypical antipsychotics. 

Tran JQ, Gerber JG, Kerr BM. Delavirdine clinical pharmacokinetics and drug interactions. Clin Pharmacokinet 2001 40 207-226. 

Bachmann KA, Ghosh R. 2001. The use of in vitro methods to predict in vivo pharmacokinetics and drug interactions. Curr Drug Metab 2 299-314. 

Zhou S, Kestell P, Paxton JW. 2002. Predicting pharmacokinetics and drug interactions in patients from in vitro and in vivo models the experience with 5,6-dimethylxanthenone-4-acetic acid (DMXAA), an anti-cancer drug eliminated mainly by conjugation. Drug Metab Rev 34 751-790. 

But even very closed Elated compounds can have widely dKient pharmacokinetics and drug interactions... 

Ereshefsky L. Pharmacokinetics and drug interactions Update for new antipsycho tics [see comments]. J Clin Psychiatry 1996 57(suppl ll) 12-25. 

Data on drug pharmacokinetics and drug interactions in patients taking treatment for HIV infection and tuberculosis are scanty, and the current recommendations are almost certain to be modified in the near future. Furthermore, it may be prudent to monitor rifampicin concentrations in the event of intolerance or adverse drug reactions. 

Ereshefsky L Pharmacokinetics and drug interactions update for new antipsychotics. J Clin Psychiatry 57(suppl ll) 12-25,1996 Escobar JI, Tuason VB Antidepressant agents a cross cultural study Psychopharmacol Bull 16 49-52,1980 Fernandez F, Ruiz P, Bing EG The mental health impact of AIDS on ethnic minorities, in Culture, Ethnicity, and Mental Illness. Edited by Gaw AC. Washington, DC, American Psychiatric Press, 1993, pp 573-586... 

In 1997, the report Pharmacokinetics and Drug Interactions in the Elderly and Special Issues in Elderly African-American Populations considered the special challenges confronted by proper use of agents in these groups. 

Funakoshi S, Murakami T, Yumoto R, Kiribayashi Y, Takano M. Role of P-glycoprotein in pharmacokinetics and drug interactions of digoxin and beta-methyldigoxin in rats. J Pharm Sci 2003 92(7) 1455-1463. 

Brosen K, Rasmussen BB. Selective Serotonin Reuptake Inhibitors Pharmacokinetics and Drug Interactions. In Feighner JP, Boyer WR, eds. Selective Serotonin Reuptake Inhibitors, 2nd Ed. 1996 87-108. 

Kosoglou T, Statkevich P, Johnson-Levonas AO, et al. Ezetimibe a review of its metabolism, pharmacokinetics, and drug interactions. Clin Pharmacokinet 2005 44 467-494. 

Extraction recovery >90%. The method can be routinely used in pharmacokinetic and drug interaction studies. An LC-MS-MS method used in a pharmacokinetic study where imatinib mesylate (Glivec) and its main metabohte (CGP74588) were measured in blood samples of a patient with end-stage renal disease on hemodialysis and compared with... 

Zech K, Steinijans VW, Huber R, Kolassa N, Radtke HW (1996) Pharmacokinetics and drug interactions - relevant factors for the choice of a drug. Int J Clin Pharmacol Ther 34(Suppl) S3-S6... 

Lambert WE, Meyer E, DeLeeheer AP, De Bersaques J, Kint AH (1992) Pharmacokinetics and drug interactions of etretinate and acitretin. J Amer Acad Dermatol 27 S19-S22... 

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