Pharmaceutical technology solid dosage forms

For process using existing technology, many of the potential variables and responses may have already been identified in previous product-development studies or in the pharmaceutical literature. Once properly identified, the list of variables and responses for the process is not likely to change appreciably. Typical variables and responses that could be expected in a granulated solid dosage form are listed in Table 1. 

APV (1981) International Association for Pharmaceutical Technology Praxis der Validierung (Validation in Practice), Symposium (1981-1982, Gelsenkirchen) [6] Terminology, sterile, semisolid, and solid dosage forms in development and production, analytical methods and stability evaluation, packaging development and packaging validation transfer, cost-effectiveness... 

Schmidt, A. G, and Picker-Freyer, K. M. (2006), Influence of mechanical activation on the micro structure of widely used excipients for solid dosage forms, paper presented at the 5th World Meeting of Pharmaceutics, Pharmaceutical Technology and Biopharmaceutics, Geneva. 

Chan HK, Chew NYK. Excipients-powder and solid dosage forms. In Swarbrick J, Boylan JC, eds. Encyclopedia of Pharmaceutical Technology, 2nd edn, vol. 2. New York Marcel Dekker, 2002 1132-1142. 

Cremer, K. Orally disintegrating dosage forms. Pharmaceutical technology. Formulation and solid dosage 2003, supplement, 22-28. 

From a physical point of view, suspensions are usually unstable systems, as the solid phase almost always tends to form a sediment. One of the most important aims with this type of dosage form must therefore be to prevent sedimentation. As this ideal condition can usually not be achieved, it is at least attempted to reduce the sedimentation rate and, above all, to make any sediment easy to redisperse. A number of auxiliaries are used in pharmaceutical technology to achieve this. They include thickeners, hydrophilic polymers, sugars and sugar alcohols, surfactants and electrolytes [296]. In spite of its insolubility, crospovidone can be classed as a hydrophilic polymer. 

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