Pharmaceutical phase

Drugp act in various ways in the body. Oral drugp go through three phases the pharmaceutic phase, pharmacokinetic phase, and pharmacodynamic phase Liquid and parenteral drug (drug given by injection) go through the later two phases only. [Pg.6]

The pharmaceutic phase of drug action is the dissolution of the dmg. Drugs must be in solution to be absorbed. Dmgi that are liquid or drugs given by injec-... [Pg.6]

The pharmaceutical phase is the time from the point of administration of the drug molecule until it is absorbed into the circulation of the body. For an orally administered drug, the pharmaceutical phase starts in the mouth and ends when the drug is absorbed across the intestinal wall. A drug may be administered either systemically, which involves... [Pg.10]

Optimization of the lead compound for the pharmacokinetic and pharmaceutical phases (section 3.5)... [Pg.108]

Once QSAR calculations have been used to optimize the pharmacodynamic interactions of the dmg molecule, the next step is to optimize the pharmacokinetic and pharmaceutical phases of dmg action. [Pg.146]

OPTIMIZING THE LEAD COMPOUND PHARMACOKINETIC AND PHARMACEUTICAL PHASES... [Pg.146]

Once the lead dmg molecule has been optimized for the pharmacodynamic phase, it must next be optimized for the pharmacokinetic and pharmaceutical phases. If a dmg molecule cannot withstand the trip from the gut to the receptor microenvironment, it makes no difference whether the drug actually binds to the receptor. [Pg.146]

Sulfonic Acids. Drugs that contain sulfonic acids are quite acidic. They have high water solubility and are rapidly excreted, leading to a rather short half-life. They can also be irritating to the gastrointestinal tract during the pharmaceutical phase. [Pg.152]

The next major consideration during optimization for the pharmacokinetic/pharmaceutical phase concerns the design of drugs to overcome barriers during their distribution. Of these barriers, the blood-brain barrier is by far the most important to the drug designer. [Pg.153]

S.G. Fleischman, S.S. Kuduva, J.A. McMahon, B. Moullton, R.D.B. Walah, N. Rodriguez-Hornedo, M.J. Zaworotko, Crystal engineering of the composition of pharmaceutical phases multiple-component crystalline solids involving carbamazepine, Cryst. Growth Des. 3 (2003) 909-919. [Pg.388]

Almarsson, 0., Zaworotko, M. J., Crystal engineering of the composition of pharmaceutical phases. Do pharmaceutical co-crystals represent a new path to improved medicines Chem. Commun. 2004, 1889-1896. [Pg.569]

Naphthalene 2-sulfonate polymer PRO 2000/5 Gel Indevus Pharmaceuticals Phase III... [Pg.844]

VEGF Trap Fusion protein, of extracellular domains of VEGFR-1 and -2 fused to the Ec portion of IgGl Regeneron Pharmaceuticals Phase I/II Exudative AMD Intravitreal injection... [Pg.35]

Pharmaceutical Phase This is the form of the drug, such as a tablet or liquid. [Pg.23]

The pharmaceutical phase is the form of the medication such as a tablet, capsule, liquid, elixirs, or syrups. The medication form contains ... [Pg.23]

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