Molecularly Imprinted Solid Phase Extraction of Pharmaceuticals

1 Molecularly Imprinted Solid Phase Extraction of Pharmaceuticals 

Molecularly imprinted solid-phase extraction (MISPE) is widely used for selective extraction of pharmaceuticals in variety of matrices (Rao et al, 2011 Javanbakht et al, 2010). The potential value of MISPE lies in the ability to selectively isolate specific compounds or their structural analogues from a complex matrix. The application of MIPs as sorbents allows not only preconcentration and cleaning of the sample but also selective extraction of the target analyte, which is important, particularly when the sample is complex and impurities can interfere with the quantification. 

Some advantages of use of MIPs in SPE are the higher sample load capacity and higher stability. The MIPs potentially offer a high level of sample cleanup than that obtained using conventional 

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