Pharmaceutical Crystalline Phases Engineering for Performance

Matthew L. Peterson, Edwin A. Collier, Magali B. Hickey, Hector Guzman and 

Pharmaceuticals continue to be an essential part of health care and everyday Ufe. In this first decade of the 21st century, the conversation about health care and pharmaceuticals revolves around value to patients. In short, there is an ever growing need to  

Meanwhile, the pharmaceutical industry s productivity has been losing ground, despite continued investments [1]. On a positive note, significant impact is emerging 

Organic Crystal Engineering Frontiers in Crystal Engineering Edited by Edward R.T. Hekink, Jagadese Vittal and Michael Zaworotko 2010, John Wiley Sons, Ltd 

Ultimately the various crystal form types give rise to solids that can exhibit markedly different performance properties , as evident by changes in solubility and dissolution or differences in chemical and physical stability. The solubility, dissolution rate and overall bioavailability of a drag will be greatly influenced by the crystal packing adopted and the surface chemistry this exposes. The crystal form can also affect the hygroscopicity 

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Multi-component Pharmaceutical Crystalline Phases Engineering for Performance... 

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