Pharmaceutical analysis Appendix

Gillings D and Koch G (1991) The application of the principle of intention-to-treat analysis of clinical trials Drug Information Journal, 25, 411-424 Greenwood M (1926) The errors of sampling of the survivorship tables Reports on Public Health and Statistical Subjects, No. 33, Appendix 1. London HMSO Grieve AP (2003) The number needed to treat a useful clinical measure or a case of the Emperor s new clothes Pharmaceutical Statistics, 2, 87-102 Haybittle JL (1971) Repeated assessment of results in clinical trials of cancer treatment British Journal of Radiology, 44, 793-797... 

This book covers the whole range of uses of chemicals within the chemical industry and downstream manufacturing sectors, as well as all their content in consumer products. Certain substances covered by specific product regulation that requires particular risk assessment and socio-economic analysis must be excluded from the scope of the research (Table 1.1). For instance, pesticides and pharmaceuticals cannot be regulated like most products produced by the chemical industry. A detailed explanation of the excluded substances is presented in Appendix 1.2 and a description of the chemical industry business activities is provided in Appendix 1.3. 

The report commented above for the determination of sulfonamides in pharmaceuticals [11] is a useful example of the development of an analytical procedure, where a sequential optimization is made. Next, the development of a procedure for the analysis of mixtures of p-blockers and diuretics [14] will show the usefulness of the interpretive optimization strategy shown in Chapter 8, which was assisted by the software (see Appendix I). 

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