Phagocytosis tumor cells

Effects of TCDD on macrophages have also been examined. When assessed ex vivo, macrophage functions such as tumor cell lysis, phagocytosis and oxidative burst were not suppressed by exposure to TCDD.9396 101 In other experimental systems, exposure to TCDD increases IL-1 and TNF production by macrophages.99 102 103 However, the ability of TCDD to alter IL-1 and TNF production is likely organ- or stimulus-specific, because in the context of respiratory viral infection, exposure to TCDD had no effect on IL-1 or TNF-a levels.80... 

Nonspecific immunity Macrophage function—in vitro phagocytosis of fluorescent covaspheres, killing of Listeria monocytogenes or of tumor cells [basal and activated by macrophage activating factor (MAF)]. 

TNF-P T cells Tumor cells, neutrophils, macrophages Cytotoxicity, phagocytosis... 

Neutrophil function (phagocytosis and bactericidal activity) Host resistance models Response to challenge with infectious agent or tumor cells... 

For complement-dependent cytotoxicity, a complex cascade of protein binding and cleavage occurs that culminates in final complement mediated effector functions of phagocytosis, recruitment and activation of leukocytes, and osmotic lysis. It has been reported that Rituximab (anti-CD20) utilizes a complement-dependent mechanism for tumor cell destruction [14], If the desired effect of a therapeutic antibody is complement-dependent activity, the isotype subgroup chosen should be one that binds to complement proteins (IgGl or IgG3). 

The final events after metallocene dichloride application are the destruction of the tumor cells and/or their phagocytosis by macrophages in vivo (Figure 3). 

Panax ginseng C.A. Mey. Araliaceae Inhibit S-180 tumor cell growth, increase production of NO, IL-ip, IL-6, IFN-y, phagocytosis, and cytotoxicity [4]"... 

Bracher M, Gould HJ, Sutton BJ, Dombrowicz D, Karagiannis SN. Three-colour flow cytometric method to measure antibody-dependent tumor cell killing by cytotoxicity and phagocytosis. Journal of Immunological Methods. 2007 323(2) 160-71. 

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