Phagocytes killing

This reaction is considered to be an important step in the phagocytic killing of microorganisms by free-radical processes (Saran et al. 1999). In this reaction, also Cl was considered to play a role (for the complexities of OH/Cl reactions in aqueous solution, see Yu and Barker 2003a,b Yu et al. 2004). 

Saran M, Beck-Speier I, Fellerhoff B, Bauer G (1999) Phagocytic killing of microorganisms by radical processes consequences of the reaction of hydroxyl radicals with chloride yielding chlorine atoms. Free Rad Biol Med 26 482-490... 

Figure 14.2 The respiratory burst in phagocytes kills bacteria.

On the other hand, cNOS is continuously expressed in the ceils, and upon stimulation of the cell, the formation of NO begins immediately. However, the amounts of NO produced are minute. The nature of NO in cells expressing cNOS is only to act as a messenger molecule, whereas NO has also other functions in cells expressing iNOS. For example, NO has bacteria and cell killing properties in immunological cells, such as phagocytes. ... 

The Respiratory Burst of Phagocytic Cells Involves NADPH Oxidase Helps Kill Bacteria... 

An alternative strategy is for the microorganism to kill the phagocyte. This can be achieved by the production of leucocidins (e.g. staphylococci, streptococci) which promote the discharge of lysosomal substances into the cytoplasm of the phagocyte rather than into the vacuole, thus directing the phagocyte s lethal activity towards itself. 

Eosinophils, which constitute only 1 to 4% of the total number of white blood cells, are only weak phagocytes. These leukocytes are produced in large numbers in individuals with internal parasitic infections. The eosinophils attach to the parasites and secrete substances that kill them, including ... 

Ability of neutrophils to destroy or kill phagocytized particles... 

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