Phage display cell-specific targeting

This problem can be overcome by a targeted approach involving generations of protein-specific probes based on DNA sequence data. These probes can be used to identify individual proteins and to investigate their functions at cell or tissue levels. This solution helps scientists to obtain useful, comprehensive and easily interpretable data. It is faster and easier than the conventional approach. These targeted molecular probes are formed using recombinant human antibodies by means of phage display technique. 

Another interesting and new application of phage display libraries is in vivo specific tissue targeting. This may be useful in targeting cells, drugs, and genes into selected tissue. In 1996 Pasqualini and Ruoslahti [44] injected phage... 

Over the past few years, a number of strategies have been developed to screen random peptide libraries for sequences targeting specific proteins. Peptides with desired binding properties can be serially selected and amplified based on a physical link with the encoding cDNA. These technologies include mRNA/DNA, viral, ribosomal, and cell displays with phage display being by far the most commonly used and probably the best understood. 

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