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Perphenazine Alcohol

Several factors increase the risk of thioridazine toxicity pre-existing cardiac disease, hypokalemia, a glucose load, alcohol, exercise, and concomitant therapy with tricyclic antidepressants, erythromycin, co-trimoxazole, cisapride, risperidone, hydroxyzine, and drugs that inhibit CYP2D6 (some SSRIs, fluphenazine, and perphenazine) (11). [Pg.365]

The following postmortem tissue concentrations were reported in a fatality due to the ingestion of about 1 g of perphenazine blood 3 pg/ml, brain 11 pg/g, liver 149 pg/g a blood-alcohol concentration of 1700 pg/ ml was also reported (R. H. Cravey, per R. C. Baselt, Disposition of Toxic Drugs and Chemicals in Man, 2nd Edn, Davis, California, Biomedical Publications, 1982, pp. 610-612). [Pg.867]

Several fatty acid esters of alcoholic phenothiazine derivatives, e.g., plpotiazlne (lb) undecyclenate and palmltate, fluphenazine enanthate and decanoate, and perphenazine enanthate, as well as the related thloxanthene, flupenthlxol decanoate, found clinical utility in antipsychotic maintenance therapy. These esters can afford advantages in absorption to enable attainment of high drug-levels in the CNS and to provide clinical efficacy of 2 to 4 weeks duration following a single injection. ... [Pg.6]


See other pages where Perphenazine Alcohol is mentioned: [Pg.562]    [Pg.50]   
See also in sourсe #XX -- [ Pg.50 ]




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