Peroxisomes cell seeding

Phorbol esters were first detected in oil prepared from seeds of Croton tiglium, and are the most widely studied skin tumor promoters however, many other chemical compounds have been shown to possess skin tumor-promoting properties, for example, phenobarbitol, DDT, and the peroxisomal prolifera-tors. Within a few hours after application of a single effective dose of phorbol 12-myristate 13-acetate (also known as TPA and 12-O-tetradecanoyTphor-boTl3-acetate, CAS 16561-29-8) to mouse skin, localized edema and erythema characteristic of inflammation and irritation are evident, and within 24 h there is leukocytic infiltration of the dermis. Within 1 or 2 days after a single promoter treatment, stimulation of mitotic activity in the basal cell layer of the epidermis is evident and continues for several days. This results in an increased number of... 

Pracharoenwattana, I., Cornah, J.E., Smith, S.M., 2005. Arabidopsis peroxisomal citrate synthase is required for fatty acid respiration and seed germination. Plant Cell 2037-2048. 

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