Peroxisome proliferator-activated receptor insulin sensitivity improvement

Improvement of insulin action in T2D subjects must therefore be a primary aim for the normalisation of blood glucose values, mainly in the postprandial state. Normalisation of insulin sensitivity in peripheral tissues in T2D has, however, never been the main objective, as we possessed no tools carrying the potential for reaching this objective. However, the recently discovered PPAR (peroxisome proliferator-activated receptor) gamma agonists, namely gUtazones, carry this potential. 

Ye, J.-M., Doyle, P.J., Iglesias, M.A., Watson, D.G., Cooney, G.J., and Kraegen, E.W. (2001) Peroxisome Proliferator Activated Receptor (PPAR)-a Activation Lowers Muscle Lipids and Improves Insulin Sensitivity in High Fat-Fed Rats, Diabetes 50,411-417. 

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