Peroxisome proliferator-activated receptor chemistry

Brown, P.J., Smith-Oliver, T.A., Charifson, P.S., Tomkinson, N.C.O., Fivush, A.M., Stembach, D.D., Wade, L.E., Orband-Miller, L., Parks, D.J., Blanchard, S.G., Kliewer, S.A., Lehmann, J.H. and Willson, T.M. Identification of Peroxisome Proliferator-activated Receptor Ligands from a Biased Chemical Library. Chemistry andBiology, 1997,4,909-918. 

Peroxisome Proliferator-Activated Receptor (PPAR), chemistry of Steroid Hormones, Biology and Biochemistry of... 

Yu S, Cao W-Q, Kashireddy P, et al. (2001) Human peroxisome proliferator-activated receptor a (PPARa) supports the induction of peroxisome proliferation in PPARa-deficient mouse liver. The Journal of Biological Chemistry 45 42485 2491. 

Banner CD, Gottlicher M, Widmark E, Sjovall J, Rafter JJ, Gustafsson J-A. 1993. A systematic analytical chemistry/cell assay approach to isolate activators of orphan nuclear receptors from biological extracts characterization of peroxisome proliferator-activated receptor activators in plasma. J. Lipid Res. 34 1583-91... 

Lehmann, J.M., Moore, L.B., Oliver, S.-T.A., Wilkison, W.O., Willson, T.M. and Kliewer, S.A. (1995) An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor. Journal of Biological Chemistry, 270, 12953-12956. 

Zhu, Y., Alvares, K., Huang, Q. et al. (1993) Cloning of a new member of the peroxisome proliferator-activated receptor gene family from mouse liver. The Journal of Biological Chemistry, 268, 26817—26820. 

A new class of peroxisome proliferator-activated receptor agonists with a novel binding epitope shows antidiabetic effects. The Journal of Biological Chemistry, 279, 41124-411 30. 

Design and synthesis of N-[(4-methoxyphenoxy)carbonyl]-N-[[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl] methyljglycine [muraglitazar/BMS-298585], a movel peroxisome proliferator-activated receptor a/y dual agonist with efficacious glucose and lipid-lowering activities. Journal of Medicinal Chemistry, 48, 2248-2250. 

Kozak, K.R., Gupta, R.A., Moody, J.S., Ji, C, Boeglin, W.E., DuBois, R.N., Brash, A.R., and Mamett, L.J. (2002) 15-Lipoxygenase metabolism of 2-arachidonylglycerol. Generation of a peroxisome proliferator-activated receptor alpha agonist. Journal of Biological Chemistry 111. 23278-23286. 

Wilkinson, A., Monteith, G., Shaw, P., Lin, C., Gidley, M., and Roberts-Thomson, S. 2008. Effects of the mango components mangiferin and quercetin and the putativemangiferimnetabo-lite norathyriol on the transactivation of peroxisome proliferator-activated receptor isoforms. J Journal of Agricultural and Food Chemistry, 56 (9), 3037-3042. 

Aoyama, T., Peters, J.M., Iritani, N., Nakajima, T., Furihata, K., Hashimoto T. and, Gonzalez, F.J., 1998. Altered constitutive expression of fatty acid-metaboUzing enzymes in mice lacking the peroxisome proliferator-activated receptor a (PPARa). Journal of Biological Chemistry 273, 5678-5684. 

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