Peroxisome-activator receptor-alpha expression

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Zhen Y, Krausz KW, Chen C, et al. Metabolomic and genetic analysis of biomarkers for peroxisome proliferator-activated receptor alpha expression and activation. Molec Endocrinol. 2007 21 2136-2151. 

Narrvula S, Colgan SP. H3fpoxia-inducible factor-1 mediated inhibition of peroxisome proliferators-activated receptor alpha expression during hypoxia. J Immunol 2001 166 7543-7548. 

Dewald O, Sharma S, Adrogue J, et al. Downregulation of peroxisome proliferator-activated receptor-alpha gene expression in a mouse model of ischemic cardiomyopathy is dependent on reactive oxygen species and prevents lipotoxicity. Circulation. Jul 19 2005 112(3) 407 15. 

Motojima, K., Passilly, R, Peters, J.M., Gonzalez, F.J. Latruffe, N. (1998) Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor alpha and gatmna activators in a tissue- and inducer-specific manner. J. biol. Chem., 273, 16710-16714... 

Lemberger T, Saladin R, Vazquez M, et al. Expression of the peroxisome proliferator-activated receptor alpha gene is stimulated by stress and follows a diurnal rhythm. J Biol Chem 1996 271 1764-1769. 

Hasmall SC, James NH, Macdonald N, et al. 2000. Species differences in response to diethylhexylphthalate suppression of apoptosis, induction of DNA synthesis and peroxisome proliferator activated receptor alpha-mediated gene expression. Arch Toxicol 74 85-91. 

Kliewer, S. A., Sundseth, S. S., Jones, S. A., Brown, P J., Wisely, G. B., Koble, C. S., Devchand, P., Wahli, W., Willson, T. M., Lenhard, J. M., and Lehmann,J. M. (1997). Fatty Acids and Eicosanoids Regulate Gene Expression Through Direct Interactions with Peroxisome Proliferator-Activated Receptors Alpha and Gamma. Proc. Natl. Acad. Sci. U.S.A. 94, 4318-4323. 

Hnang B, Wn P, Bowker-Kinley MM, and Harris RA (2002) Regnlation of pyruvate dehydrogenase kinase expression hy peroxisome proliferator-activated receptor-alpha ligands, glucocorticoids, and insulin. Diabetes 51,276-83. 

Sugden MC, Bulmer K, Augustine D, and Holness MJ (2001a) Selective modification of pyruvate dehydrogenase kinase isoform expression in rat pancreatic islets elicited by starvation and activation of peroxisome proliferator-activated receptor-alpha implications for glucose-stimulated insulin secretion. Diabetes 50, 2729-36. 

P. Razeghi, M. E. Young, S. Abbasi, and H. Taegtmeyer, Hypoxia in vivo decreases peroxisome proliferator-activated receptor alpha-regulated gene expression in rat heart, Biochem Biophys Res Commun 287,5-10(2001). 

Yamazaki K, Kuromitsu J, Tanaka I (2002) Microarray analysis of gene expression changes in mouse liver induced by peroxisome proliferator-activated receptor alpha agonists. Biochem Biophys Res Commun 290 1114-1122... 

Anderson, S. R, Howroyd, P., Liu, J., Qian, X., Bahnemann, R., Swanson, C., Kwak, M. K., Kensler, T. W., and Corton, J. C. (2004b). The transcriptional response to a peroxisome proliferator-activated receptor alpha agonist includes increased expression of proteome maintenance genes. J Biot Chem 279, 52390-52398. 

Hsu, M. H., Savas, U., Griffin, K. J., and Johnson, E. F. (2001). Identification of peroxisome proliferator-responsive human genes by elevated expression of the peroxisome proUferator-activated receptor alpha in HepG2 cells. J Biol Chem 276, 27950-27958. 

B. (2003) Peroxisome proliferator-activated receptor alpha induces hepatic expression of the human bile acid glucuronidating UDP-glucuronosyltransferase 2B4 enzyme. J. Biol. Chem. 278, 32852-32860. 

Sakai, M., Matsushima-Hibiya, Y., Nishizawa, M., and Nishi, S. (1995) Suppression of rat glutathione transferase P expression by peroxisome proliferators interaction between Jun and peroxisome proliferator-activated receptor alpha. Cancer Res. 55, 5370-5376. 

Kok, T., Bloks, V. W., Wolters, H., Havinga, R., Jansen, P. L., Staels, B., and Kuipers, F. (2003) Peroxisome proliferator-activated receptor alpha (PPARalpha)-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in mice. Biochem. J. 369, 539-547. 

Barbier, O., Duran-Sandoval, D., Pineda-Torra, I., Kosykh, V., Fruchart, J. C., and Staels, B. (2003) Peroxisome proliferator-activated receptor alpha induces hepatic expression of the human bile acid glucuronidating UDP-glucuronosyltransferase 2B4 enzyme. J. Biol. Chem. 278, 32852-32860. 

Fang, H. L., Strom, S. C., Cai, H., Falany, C. N., Kocarek, T. A., and Runge-Morris, M. (2005) Regulation of human hepatic hydroxysteroid sulfotransferase gene expression by the peroxisome proliferator-activated receptor alpha transcription factor. Mol. Pharmacol. 67, 1257-1267. 

Aoyama, T., Peters, J. M., Iritani, N., Nakajima, T., Furihata, K., Hashimoto, T., and Gonzalez, F. J. Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor alpha (PPARalpha). J Biol Chem 273 (1998) 5678-5684. 

Patsouris, D., Reddy, J. K., Muller, M., and Kersten, S. Peroxisome proliferator-activated receptor alpha mediates the effects of high-fat diet on hepatic gene expression. Endocrinology 147 (2006) 1508-1516. 

Peters, J. M., Park, Y., Gonzalez, F. J., and Pariza, M. W. Influence of conjugated linoleic acid on body composition and target gene expression in peroxisome proliferator-activated receptor alpha-null mice. Biochim Biophys Acta 1533 (2001) 233-242. 

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