Periodontal disease detection

Various volatile compounds such as skatole, indole, sulfides, and long chain alcohols have been identified in the headspace of saliva samples. These materials increase in both a quantitative and qualitative fashion with varying degrees of periodontitis. Specifically, alkyl pyridines appear to be present in the saliva only in individuals with periodontal disease. The monitoring of these compounds may allow the detection of the early stages of this disease process which effects 60-70% of the population. 

Elevated plasma levels of IL-1 have been detected in a wide range of different conditions that are characterized by inflammation such as rheumatoid arthritis (RA), acute arthritides (D13, E2, M5), Crohns disease (SIO), periodontitis (C16), sunburn (G20), bums (K34), endometriosis (F3), psoriasis (C5), gram-positive meningitis (Sll), and extended exercise in healthy volunteers (C9). In RA there is some correlation with disease activity (E2). In synovial fluid, biologically active... 

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