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Peptides high-throughput profiling

The other approach to quantitative protein profiling is based on stable isotope labelling of proteins and peptides and automated tandem mass spectrometiy (MS/MS) (Gygi et al., 1999b). This method, termed isotope-coded affinity tag labelling or ICAT, has been shown to be robust, reproducible and amenable to high throughput automation (Ideker et al.,... [Pg.176]

Gosalia, D. N., Salisbury, C. M., Ellman, J. A., and Diamond, S. L. 2005. High throughput substrate specificity profiling of serine and cysteine proteases using solution-phase fluorogenic peptide microarrays. Mol. Cell. Proteomics 4 626-36. [Pg.44]

Computational Analysis of High-Throughput MALDI-TOF-MS-Based Peptide Profiling... [Pg.411]

The MALDI-TOF-MS platform is able to perform high-throughput quantitative peptide profiling using biofluids, in parhcular serum, which is highly relevant for chnical use. It has been shown that semm and CSF peptide mass profiles can be correlated to clinical data for disease signature discovery and validation. [Pg.426]

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Computational Analysis of High-Throughput MALDI-TOF-MS-Based Peptide Profiling

High peptide profiling

High-throughput

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