Computational Analysis of High-Throughput MALDI-TOF-MS-Based Peptide Profiling

Computational Analysis of High-Throughput MALDI-TOF-MS-Based Peptide Profiling 

MALDl MS A Practical Guide to Instrumentation, Methotk, and Applications, Second Edition. 

Edited by Franz Hillenkamp and Jasna Peter-Katalinic. 

Background subtraction Peak detection Alignment Deisotoping Normalization 

Background subtraction. This step is also referred to as baseline subtraction or baseline correction. Raw MALDI-MS signals exhibit a global variation in the baseline that varies from spectrum to spectrum, and must be corrected. The baselines vary slowly and smoothly as the mass increases. Hence, the aim here 

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