Peptidergic Influences on Glucose Utilization

With the advent of the autoradiographic deoxyglucose technique (Kennedy et al, 1975 Sokoloff et al, 1977) at a time when investigations 

The acute administration of morphine resulted in marked, global reductions in cerebral glucose utilization (Sakurada et aL, 1976). However, the depressed glucose use appeared to result from the hypercapnia associated with the administration of morphine, rather than a functional consequence of the drug s action within the CNS (see Section 2.5.1) (Sakurada et aL, 1976). 

A portion of the adrenocorticotrophic hormone (ACTH) molecule (the amino acid residues H-Met-Glu-His-Phe-Arg-Try-Gly-OH, ACTH4 g) has long been recognized to have marked effects upon motivational. 

The implication of the two regions of the hippocampus on the gasis of altered glucose utilization is of particular interest in view of the involvement of the hippocampus not only in the action of ACTH and its analog, but in learning and memory processes in general (Isaacson and 

Pribram, 1975). The stratum moleculare lacunosum gives rise to few, if any, fibers which terminate outside of the hippocampal formation, but has extensive, diverse intrahippocampal connections (Swanson and Cowan, 1977). In contrast, the parasubiculum is the origin of the major hippocampal projection to the mamillary body and, of particular interest in relation to the observed alterations in glucose utilization, to the anterior thalamic nucleus (Powell and Hines, 1975 Swanson and Cowan, 1977). The anterior nucleus of the thalamus and anterior cingulate cortex possess extensive reciprocal connections with each other (Domesick, 1969 Beckstead et ai, 

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