Peptide synthesis vessel block

Peptide synthesis resins are extremely fragile and the beads, if wrongly handled, can easily fracture, leading to the generation of fines which can block reaction vessel filter-frits and solvent lines. 

One particular asset of structured self-assemblies is their ability to create nano- to microsized domains, snch as cavities, that could be exploited for chemical synthesis and catalysis. Many kinds of organized self-assemblies have been proved to act as efficient nanoreactors, and several chapters of this book discnss some of them such as small discrete supramolecular vessels (Chapter Reactivity In Nanoscale Vessels, Supramolecular Reactivity), dendrimers (Chapter Supramolecular Dendrlmer Chemistry, Soft Matter), or protein cages and virus capsids (Chapter Viruses as Self-Assembled Templates, Self-Processes). In this chapter, we focus on larger and softer self-assembled structures such as micelles, vesicles, liquid crystals (LCs), or gels, which are made of surfactants, block copolymers, or amphiphilic peptides. In addition, only the systems that present a high kinetic lability (i.e., dynamic) of their aggregated building blocks are considered more static objects such as most of polymersomes and molecularly imprinted polymers are discussed elsewhere (Chapters Assembly of Block Copolymers and Molecularly Imprinted Polymers, Soft Matter, respectively). Finally, for each of these dynamic systems, we describe their functional properties with respect to their potential for the promotion and catalysis of molecular and biomolecu-lar transformations, polymerization, self-replication, metal colloid formation, and mineralization processes. 

Different instruments are now available for automated synthesis on solid phase. The Applied Biosystems peptide synthesizer ABl 433 (Fig. 3) was chosen as an initial platform due to its wide availability and the few modifications necessary for its application to oligosaccharide synthesis. The custom-made reaction vessel is constructed of jacketed glass to allow cooling. The building blocks are placed in cartridges to be delivered sequentially. The synthesizer allows for nine different solvents and reagents. A new, more versatile and less... 

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