Peptide hydrogens from

Sheinblatt, M. (1970) Determination of an acidity scale for peptide hydrogens from nuclear magnetic resonance kinetic studies. J Am Chem Soc, 92 (8), 2505-2509. 

Fig. 19 Another proposed mechanism of peptide synthesis catalyzed by the ribosome. The P-site 2 -OH group abstracts a hydrogen from the amino group [161]...

The influence of proline residues on coordination has been examined by Kozlowski and coworkers. Where Pro occurs in a peptide chain there is no peptide hydrogen (20), and from a variety of spectroscopic studies these workers have established that a Pro residue causes disruption of metal ion-promoted peptide ionizations, i.e. Pro serves as a breaking point in metal ion coordination. On... 

Table VII. Ionization Constants for the Loss of Coordinated Amine Hydrogens from Cu(III)—Peptide Complexes0...

In fact, in trypsin 27% (36 sites) of the fully exchanged peptide hydrogens are buried more than 4 A from the surface, and 15% (20 sites) are even 5 A or deeper. H is replaced by D in these peptide groups, because there are internal, fully D20-exchanged water molecules in trypsin, and the average distance between them and the exchanged peptide H s is around 2.5 A. 

It is often reserved as the drug of last resort . Vancomycin has increasingly become a first-line therapy in resistant Staphylococcus aureus infections. Vancomycin prevents NAM acid and NAG-peptide subunits from being incorporated into the peptidoglycan matrix the large hydrophilic molecule forms hydrogen-bond interactions with the terminal D-alanyl-D-alanine moieties of the NAM/NAG-peptides (Figure 20.8). 

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