Peptic ulcer disease histamine receptor antagonist

Intravenous histamine-2-receptor antagonists such as ranitidine, famotidine, and cimetidine are compatible with PN and can be added to the daily PN for prevention of stress-related mucosal damage and peptic ulcer disease. This provides a continuous acid suppression and reduces nursing time by avoiding intermittent scheduled infusions. 

Effects of histamine on blood pressure and heart rate in humans. Histamine was infused at 40 u g/kg/h for 5 minutes as shown at the top of the panel. (Modified and reproduced, with permission, from Torsoli A, Lucchelli PE, Brimblecombe RW [editors] H-Antagonists H2 Receptor Antagonists in Peptic Ulcer Disease and Progress in Histamine Research. Excerpta Medica, 1980.)... 

The discovery and development of cimetidine and ranitidine provided a revolution in the medical treatment and management of peptic ulcer disease. Subsequently, many pharmaceutical companies became involved in research programs to discover additional compounds as H2-receptor histamine antagonists. As a result, a very wide range of chemical structures now exists for this class of drug (for a review, see Cooper et al. [19]). Many of these compounds have been investigated in human studies, but only the above-mentioned five drugs - cimetidine, ranitidine, nizatidine, famotidine, and roxatidine - are marketed as medicines. 

As stated above, cimetidine revolutionized the medical treatment of peptic ulcer disease, and other products which followed continued the same type of treatment. Thus, H2-receptor histamine antagonists in general were given daily for 4—6 weeks... 

The involvement of more than one endocrine hormone and neurotransmitter in the control of gastric acid secretion has resulted in a number of therapeutic approaches directed toward achieving its inhibition. Of these strategies both muscarinic and histamine Hg-receptor antagonists have been used, with the latter being the method of choice for the control of acid-related disorders, particularly peptic ulcer disease, until the late 1980s. Along with the successful treatment of many patients... 

Hi receptor antagonists are applied in the treatment of allergy and Hz receptor antagonists have been shown to be very effective in the inhibition of gastric acid secretion and have greatly improved the treatment of individuals with peptic ulcer disease and acid reflux esophagitis. Histamine is present in abundance in many dietary sources no beneficial effects of supplementation of either histidine or histamine are known. 

Ranitidine Zantac Azantac Melfax Rantec Sostril Taural Histamine Hj-receptor antagonist mp 70 °C Soluble in water. Treatment of peptic ulcer, gastrointestinal bleeding, and gastroesophageal reflux disease. N02 H H... 

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