Pentachlorophenyl

The first detailed investigation of the reaction kinetics was reported in 1984 (68). The reaction of bis(pentachlorophenyl) oxalate [1173-75-7] (PCPO) and hydrogen peroxide cataly2ed by sodium saUcylate in chlorobenzene produced chemiluminescence from diphenylamine (DPA) as a simple time—intensity profile from which a chemiluminescence decay rate constant could be determined. These studies demonstrated a first-order dependence for both PCPO and hydrogen peroxide and a zero-order dependence on the fluorescer in accord with an earher study (9). Furthermore, the chemiluminescence quantum efficiencies Qc) are dependent on the ease of oxidation of the fluorescer, an unstable, short-hved intermediate (r = 0.5 /is) serves as the chemical activator, and such a short-hved species "is not consistent with attempts to identify a relatively stable dioxetane as the intermediate" (68). 

A general step ahead in polycondensation was achieved by the application of the active ester method by DeTar et al.19) and Kovacs et al.291 Very soon, the nitrophenyl ester, the pentachlorophenyl ester, or the hydroxysucdnimido ester were used exclusively. The esters of the protected tripeptides could be purified by crystallization, then the N-protecting group was split off and the free peptide esters were purified again. Addition of base starts the polycondensation, resulting quickly in the formation of a viscous solution at low temperature. 

S.P. solid-phase technique L.P. liquid-phase technique OPTcp pentachlorophenyl ester TEEP tetraethyl pyrophosphit OTCp trichlorophenyl ester ONp p-nitrophenyl ester ONSu N-hydroxysuccinimido ester OPFp pentafluorophenyl ester OQu 8-hydroxyquinyl ester OPy 3-hydroxy-pyridyl ester ODnp 2,4-dinitrophenyl ester DCC dicyclohexylcarbodiimide HOBn 3-hydroxy-4-oxo-3,4-dihydro-l,2,3-benzotriazin Opi JV-hy-droxypiperidine EEDQ 2-ethoxy-l-ethoxycarbonyl-l,2-dihydroquinoline Tos p-toluenesulfonyl PTC propanetricarboxylic acid OBu tm-butyl ester Nva norvaline Aha aminohexanoic acid Om ornithine... 

Arylgold(I) compounds can be similarly prepared to alkyl derivatives via the organolithium or the Gridnard route. These methods have been used to prepare pentachlorophenyl,1641 4,4 -octa-fluorobiphenyl (Equation (27)),2109 2,4,6-tris(trifluoromethyl)phenyl,1 2,21 0 triphenylar-... 

We were able to prepare pentachlorophenylmagnesium chloride 5>, pentachlorophenyl-lithium 7 9>, and tetrachloroanthranilic acid 19>, relatively easily. However, we found that pentabromophenyl-lithium could not be formed in an acceptable yield from hexabromobenzene and that tetrabromoanthranilic acid was not readily available by the published methods. The preparation of tetrabromoanthranilic acid, in high yield (>85%), has now been achieved, and we find that all of the tetra-halogenbenzynes react with benzene with the exclusive formation of the 1,4-cyclo-adduct in good yield. The adduct of tetrabromobenzyne with benzene has been prepared very recently in 3% yield from pentabromophenyl-lithium 58>. 

In supplying a calender with a strip of warmed compound by means of a narrow conveyor belt, the final section of the belt may be arranged to oscillate back and forth across the calender nip the device is termed a pendulum feed. Pentachlorophenyl Laurate PCPL, latex auxiliary. 

Naphthalene-2,3-dicarboxaldehyde Nicotinamide adenine dinucleotide N-Acetylneuraminic acid 4-Fluoro-7-nitrobenzoxadiazole Naphthalene-2,3-dicarboxaldehyde Nondestructive readout Near infrared Near infrared fluorescence Nuclear magnetic resonance 2-Nitrophenyl oxalate 1,1 -Oxalyldiimidazole Polycyclic aromatic hydrocarbon Principal component analysis Photosensitized chemiluminescence Pentachlorophenyl oxalate Polymerase chain reaction... 

J Kovacs, R Gianotti, A Kapoor. Polypeptides with known repeating sequence of amino acids. Synthesis of poly-L-glutamyl-L-alanyl-L-glutamic acid and polyglycyl-L-phenylalanine through pentachlorophenyl active ester. J Am Chem Soc 88, 2282, 1966. 

L Kisfaludy, MQ Ceprini, B Rakoczy, J Kovacs. Pentachlorophenyl and pentafluo-rophenyl esters of peptides and the problem of racemization II, in HC Beyerman, A van de Linde, W Massen van den Brink, eds. Peptides, Proceedings of the 8th European Peptide Symposium, North-Holland, Amsterdam, 1967, pp 25-27. 

G Kupryszewski, M Formela. Amino acid chlorophenyl esters. HI N-Protected amino acid pentachlorophenyl esters. Rocz Chem 35, 931, 1961. 

The isolated conjugate was identified as pentachlorophenyl-sulfate by precipitation with BaCl2, by column and thin-layer chromatography, by UV-absorption spectra, and by determination of the molar ratio of PCP to SO4. PCP-glucuronide which is excreted in bile was not detected(j0. 

Kinetic studies of the alkaline hydrolyses (pH 11-14) of a series of pentachlorophenyl esters of >-(/7-hydroxyphenyl)alkanoic acids (19 m = 1-4) have been reported. The reasonably high nucleofugality of the pentachlorophenoxide (pK ... 

Synonyms AI3-01719 AIDS-17533 Amatin Anticarie BRN 1912585 Bunt-cure Bunt-no-more Caswell No. 477 CCRIS 325 Co-op hexa EINECS 204-273-9 ENT 1719 EPA pesticide chemical code 061001 Granox Granox NM HCB HCBz Hexa C.B. Julen s carbon chloride Julian s carbon chloride Julin s carbon chloride Julin s chloride No bunt No bunt 40 No bunt 80 No bunt liquid NSC 9243 Pentachlorophenyl chloride Perchlorobenzene Phenyl perchloryl RCRA waste number U127 Sanocid Sanocide Smut-go Snieciotox UN 2729 Voronit C. 

Uses Manufacture of insecticides (termite control), algicides, herbicides, fungicides, and bactericides wood preservative. Manufacture of pentachlorophenyl laurate to mothproofing fabrics. 

Octachlorodibenzothiophene (88) has been formed by irradiation of a solution of pentachlorobenzenesulfenyl chloride in CCI4 in a low-pressure, cold cathode mercury arc (62%). A similar photolysis of bis-(pentachlorophenyl) sulfide, prepared by the action of sulfur monochloride and sulfuryl chloride on benzene in the presence of aluminum chloride, also yielded 88 (42%). Both routes are shown in Scheme 4. 

Synonyms Hexachlorobenzol perchloroben-zene HCB pentachlorophenyl chloride... 

Methylene chloride-soluble residues. Methylene chloride-or chloroform-soluble C-labeled products were major residues in all of the plant tissues examined except peanut cell ciiltures (Figure 3). Chloroform-soluble C accounted for 59.2 of the radioactivity isolated from peanut roots 48 hr after treatment with [ C]PCNB. The radioactivity was in the form of PCNB (28.7 ), pentachloroaniline (22.5 ), pentachlorothiophenol (2.6 ) pentachlorothloanlsole (3.1 ) pentachlorothloanlsole sulfoxide (0.5 ) S-(pentachlorophenyl)-2-thioaoetic acid [(S-(PCP)ThioAcetate] (0.5 ) and S-(pentachlorophenyl)-3-thio-2-hydroxypropionic acid [S-(PCP)ThioLactate] (0.2 ) and S-(PCP)Cys (trace) (J), The structures of these compounds are shown in Figure 13. Based on TLC, the last three compounds in this list were classified as polar chloroform- or methylene chloride-soluble residues and the remaining compounds were classified as nonpolar residues. 

S-PENTACHLOROPHENYL-2- S-PENTACHLOROPHENYL-2-THIOACETIC ACID HYDROXY-3-THIOPROPIONIC ACID... 

Insoluble residue was the most abundant product of penta-chlorothiophenol metabolism in peanut. The importance of this process is obviously dependent upon the presence of an active C-S lyase system. S-(Pentachlorophenyl)cysteine was also a precursor of insoluble residue in peanut, but the extent to which this involved pentachlorothlophenol as an intermediate was not determined. Additional studies are needed to determine if insoluble residues are commonly formed from GSH conjugates by other routes. 

S-(Pentachlorophenyl)-2-thioacetic acid and S-(PCP)Thio-Lactate were thought to be produced from S-(PCP)Cys by a transamination reaction. S-(Pentachlorophenyl)-2-thioacetic acid accounted for 7.3J of the in peanut roots treated with S-(PCP)Cys. S-(Pentachlorophenyl)-2-hydroxy-3-thiol-propionic acid and S-(PCP)ThioAcetate were minor metabolites and their presence was not definitively established in tissues other than peanut root. 

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