Penicillium aurantiogriseum

In stationary liquid cultures of Penicillium aurantiogriseum the direct incorporation of [carftoxy- C]anthranilic acid, [U- C]glutamine, and [U- " C]glutamic acid into auranthine (5) has been demonstrated. [U- C]Omithine was likewise incorporated, but at a lower rate 85,86). These data, together with the spectral evidence of the molecular structure 85) (see Table II), indicate that the alkaloid is synthesized from two molecules of anthranilic acid and one glutamine 86). 

Yeulet SE, Mantle PG, Rudge MS, Greig JB. Nephrotoxicity of Penicillium aurantiogriseum, a possible factor in the aetiology of Balkan endemic nephropathy. Mycopathologia 1988 102 21-30. 

The fungus Penicillium aurantiogriseum SPO-19, isolated from the Chinese sponge Alycale plumose, yielded three new quinazoline alkaloids, aurantiomides A (167), B (168), and C (169). Structurally, 167—169 are closely related to anacine, a metabolite previously described from terrestrial strains of P. aurantiogriseum and P. verrucosum and which based on its structure is most likely formed by incorporating anthranilic acid into a diketopiperazine composed of leucine and glutamine. Compounds 168 and 169 showed moderate cytotoxic activities toward various cell lines, while 167 was inactive. 

Vesely D, Vesela D, Jelinek R (1995) Penicillium aurantiogriseum Dierckx Produces Chaetoglobosin A Toxic to Embryonic Chickens. Mycopathologia 132 31... 

Cyclopiazonic acid 2 Cheese (cmst), maize, groundnuts, millet Aspergillus flavus Penicillium aurantiogriseum... 

Some other examples of pyrone-type polyketides were isolated from Penicillium aurantiogriseum and Trichoderma koningii collected on muds from Bohai Sea, China, and South China Sea, respectively. 

L. (2010) Verrucosidinol and verrucosidinol acetate, two pyrone-type polyketides isolated from a marine derived fimgus, Penicillium aurantiogriseum. Mar. Drugs. 8, 2744-2754. 

Penicillium cyclopium Westling is renamed P. aurantiogriseum Dierckx. 

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