Penicillin V calcium

Figure 9.16 The correlation of blood penicillin concentrations at 0.5 h in fasting subjects following the oral administration of three different penicillin V salts (potassium penicillin V, calcium penicillin V and penicillin V) with the in v/trorates of dissolution. Line YvsX is a plot of average plasma penicillin concentration at 0.5 h versus penicillin V in solution after 10 min at pH 2.0. Line Y vs X is average (AUC) versus penicillin V in solution after 10 min at pH 2.0. Line Y vs X is average (ADC) versus penicillin V in solution after 10 min at pH 8.0. In each case, the points from left to right refer to penicillin V, calcium penicillin V and potassium penicillin V. (Juncher ef o/., 1957).

Amphotericin A Amphotericin B Ampicillin trihydrate Benzathine penicillin V Calcium amphomycin Chloramphenicol palmitate Chloroprocaine penicillin O Colistin sulfate Cycloserine free acid Dactinomycin... 

Like penicillin G, penicillin V is also available in a number of different salts either with inorganic ions including sodium, potassium, or calcium, or with organic cations including benzathine and hydrabramine. These salts have differing solubilities and hence differing duration of action. 

The principal penicillins of present importance are benzylpenicillin sodium or potassium salt (penicillin G) procaine benzylpenicillin benzathine penicillin benethamine penicillin phenoxymethylpenicillin, potassium or calcium salt (penicillin V) methicillin sodium phenethicillin sodium penicillamine hydrochloride. 

Penicillins G and V (119) have been reported to cause neuromuscular block in animal preparations, but only at exceptionally high doses. Calcium is effective in reversal. The acylaminopenicillins augment vecuronium-induced blockade (120). Possible re-curarization with piperacillin was successfully reversed by neostigmine (121). 

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