Benethamine penicillin

Benethamine Penicilline Benzilpenicillin Penicillin G se depot antibiotic Benzathine)... 

Penicillin G (VI) is widely used in veterinary medicine principally in controlled release penicillin G complexes such as procaine penicillin G, penicillin G benzathine and benethamine penicillin G. Penicillin G, in its complex with procaine (VII) has antibacterial activity in horses, cattle, sheep, cats and dogs and is manufactured by many drug firms, either as the complex on its own or mixed with other antibiotics such as streptomycins. 

The principal penicillins of present importance are benzylpenicillin sodium or potassium salt (penicillin G) procaine benzylpenicillin benzathine penicillin benethamine penicillin phenoxymethylpenicillin, potassium or calcium salt (penicillin V) methicillin sodium phenethicillin sodium penicillamine hydrochloride. 

Benethamine Penicillin, Ci5Hi7N,CigHig04N2S, Mol. Wt. 545 7. Benethamine penicillin is the A -benzylphenethylamine salt of benzyl-penicillin and its potency is determined by microbiological assay (p, 814) using the Standard Preparation of Penicillin as standard. 

Benzylpenicillin is rapidly absoibed and rapidly excreted However, certain sparingly soluble salts of benzylpenicillin (benzathine, benethamine and procaine) slowly release penicillin into the circulation over a period of time, thus giving a continuous high concentration in the blood. Simultaneous administration of benzylpenicillin (see Fortified Proeaine Penieillin, BP) may be given initially. 

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