Penicillin G, procaine

De Rose, A.F. U.S. Patent 2312,326 November 5,1957 assigned to Abbott Laboratories 

Chemical Name Penicillin G compound with 2-(diethylamino)ethyl p-aminobenzoate Common Name — 

Trade Name Manufacturer Country Year (ntroduodd 

Trade Name Manufacturar Country Year Introduced 

There was added to 250 ml of a concentrated butyl acetate extract containing 74,000 units of the acid form of penicillin per ml, 50 ml of a butyl acetate solution containing 0.238 g per ml of procaine base. The solution was agitated for one hour. The precipitate which formed was very gummy and not in the form of discrete crystals. This precipitate was crystallized by scratching the side of the vessel and agitating further. After this treatment 18.25 g of crystalline procaine penicillin was obtained which assayed 1010 units per mg representing a yield of 99.6% of the activity contained in the concentrated extract. 

Bardolph, M.P. U.S. Patent 2,739962 March 27, 1956 assigned to Commercial Solvents Corp. 

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Two basic methods are used to prepare parenteral suspensions (a) sterile vehicle and powder are combined aseptically, or (b) sterile solutions are combined and the crystals formed in situ. Examples of these procedures may be illustrated using Penicillin G Procaine Injectable Suspension USP and Sterile Testosterone Injectable Suspension USP. 

Penicillin G procaine and benzathine mixture Not recommended in adolescents and adults 12 million units (benzathine 0,9 million units, procaine 03 million units) One dose... 

Penicillin G Benzathine 55 Penicillin G Potassium 55 Penicillin G Procaine 55 Penidllin V 55 Pentam 55 Pentamidine 55 Pentasa 47 Pentazodne 82 Pentids 55 Pentosan 55 Pentoxifylline 55 Pepcid... 

Gonorrhea (uncomplicated) - Give probenecid as a single 1g dose immediately before or with 4.8 million units penicillin G procaine, aqueous, divided into at least 2 doses. 

PENICILLIN G PROCAINE, /M. Administer by deep IM injection only into the upper outer quadrant of the buttock. In infants and small children, the midlateral aspect of the thigh may be preferable. When doses are repeated, rotate the injection site. Do not administer IV. 

Procaine sensitivity If sensitivity to the procaine in penicillin G procaine is suspected, inject 0.1 mL of a 1% to 2% procaine solution intradermally. 

Penicillin G Procaine (Wycillin/ Others) [Antibiotic/Penicillin]... 

I Brand Name(s) Penicillin G Procaine-. Crysticillin, Wycillin... 

Parenteral 0.6, 1.2, 2.4 million units per dose Penicillin G procaine (generic)... 

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