PDMS microfluidic devices

Usui, S., Fujii, T., Development of in situ flow-through analyzer of Mn2+ in seawater with a PDMS microfluidic device. Micro Total Analysis Systems 2003, Proceedings 7th fiTAS Symposium, Squaw Valley, CA, Oct. 5-9, 2003, 291-294. 

Figure 11. (A) Scheme of the PDMS microfluidic device. Inset channel crossing with the cell trap composed of microstmctured obstacles, (B) Scanning electron micrograph of the cell trap, (C) single cell in a channel navigated by optical tweezers in the microchannel, (D-G) optical micrographs of a single cell at the injection position during SDS lysis. SDS flow is from channel 4 through the cell trap into channel 2.

Kanai M, Uchida D, Sugiura S, Shirasaki Y, Go JS, Nakanishi H, Funatsu T, Shoji S (2003) PDMS microfluidic devices with PTFE passivated channels. In 7th International conference on micro total analysis systems pTAS2003, vol 1, Squaw Valley, pp 429-432... 

Microfabricated Multichannel Electrospray Ionization Emitters on Polydimethylsiloxane (PDMS) Microfluidic Devices... 

In this approach, a mask with desired geometry is inserted in the microscope to generate a mask-defined UV light beam projection on the monomer stream flowing in a polydimethylsiloxane (PDMS) microfluidics device described earlier. 

Various PDMS-based tunable optofluidic devices have been developed in the past few years for different applications. In these devices, such pressure tuning methods have many advantages, such as high precision, fast response, compact size, simple fabrication, easy control, and being compatible with other PDMS microfluidic devices in terms of both fabrication and operation. Moreover, multiple such tunable optofluidic elements can be integrated into a single chip, while each of them can be independently controlled. 

In 2004, Hisamoto and coworkers [19] have presented a simple approach, called capillary-assembled microchips (CAs-CHIP), for assembling a commercial square fused-silica capillaiy into a PDMS microfluidic device. The capUlaiy could be completely functionalized off-chip and cut into required size and then integrated raito a chip without any solution leakage (as shown in Fig. 3). As many methods for surface modification of capillary have been well established, the CAs-CHIP method offered a way to fabricate different microfluidic devices having various functions for analytical applications including sample pretreatment, biochemical sensors, and so on. 

Microfluidic Chip-Based Electrochromatography, Fig. 3 General fabrication ofCAs-CHIPby embedding square capillaries into the PDMS microfluidic devices (Reprinted with permission from [19])... 

A detective system by integration of fluorescence detector based on a microavalanche photodiode into a PDMS microfluidic device [3,4]... 

Wu et al. [23] designed a PDMS microfluidic device for chemical cytometry, cOTisisting of integrated valves which formed a reactirai chamber... 

Quake and coworkers [16] developed a PDMS microfluidic device (shown in Fig. 4c) for nucleic acid purification from a small number of bacterial or mammalian cells. This multilayer device contained fluidic channels and a system of membrane-actuated pneumatic valves and pumps, which enabled precise control of buffers, lysis agents, and cell solution and also allowed for parallel processing. Bacterial cells, dilution buffer, and lysis buffer are first introduced into the chip and then transferred into the rotary mixer. Once mixed, the lysate is flushed over a DNA affinity column and drained. The DNA... 

Figure 6 (a) Photograph of the PDMS microfluidic device, (b) Graphical representations of the on-chip approach toward the preparation of size- and snrface-chemistry-controllable RGD-SNPs. 

EGDA is a cross-linker that has been employed repeatedly in iCVD polymerization to enhance the mechanical properties of the film [67,68]. p(PFDA-co-EGDA) was deposited in channels of poly(dimethylsiloxane) (PDMS) microfluidic devices as a barrier coating to prevent diffusion and swelling [50] or to provide an adequate interface for the synthesis of nanoparticles in droplet-flow microfluidic reactors [52]. p(PFDA-co-EGDA) was used to robustly encapsulate IL marbles [51]. IL marbles were fabricated rolling off a droplet of IL in a Petri dish with FI FE microparticles. Next, the Petri dish was placed inside the vacuum chamber and the marbles were conformally coated over the entire surface. 

Apart from OLEDs, use of inorganic thin-film LEDs has also been integrated into microfluidic chips. A portable microassembly of a fluorescence detection system was illustrated by Chediak et al. [10] wherein a CdS thin-fihn filter and an (In, Ga)N thin-fihn blue LED was integrated with a disposable PDMS microfluidic device with Si PIN photodetector substrate. 

Figure 9.28 (A) Schematic representation of PDMS microfluidic device on ZnSe ATR prism and mixing setup. (B) ATR FT-IR images (a-c) show the abundance of DjO,...

Emulsification of the aqueous siliceous precursor was achieved by supplying the aqueous (sol-gel solution) phase and the oil phase to the microfluidic device using two syringe pumps. The continuous phase was prepared by dissolving ABIL EM 90 surfactant in hexadecane, which served as the emulsifier. The SU-8 photoresist-templated PDMS microfluidic device was fabricated using a well-established soft lithography method [10], The microfluidic devices used in this study is shown in Figure 19.7. 

Keywords Polydimethylsiloxane (PDMS), microfluidic devices, surface modification, physical adsorption, inner migration, high... 

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